INT323897

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.80
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
cartilage 2
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 91.84 High High
metalloproteinase 3 23.44 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 104 100.00 Very High Very High Very High
Stomach Cancer 108 99.84 Very High Very High Very High
Cancer 62 98.32 Very High Very High Very High
Aging 36 96.48 Very High Very High Very High
Overweight 13 95.96 Very High Very High Very High
Osteoarthritis 54 91.84 High High
Colon Cancer 4 86.88 High High
Adenocarcinoma 2 85.88 High High
Thyroid Neoplasm 2 84.80 Quite High
Metastasis 36 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Bmi-1 has been shown to immortalize and transform normal human cells via inhibiting cellular senescence, which constitutes a powerful barrier to oncogenesis [8,11].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Bmi-1 associated with aging
1) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.77 Pain Relevance 0
Recently we reported that Bmi-1 was overexpressed in gastric cancer cell lines and gastric tumors and plays an important role in the carcinogenesis and progression of gastric cancer [10].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Bmi-1 associated with cancer and stomach cancer
2) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.67 Pain Relevance 0
Consequently, leptin may protect cartilage from the degenerative process in patients with BMI of more than 30 kg/m2 through overexpression of genes encoding IGF-1, type 2 collagen and TIMP-2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BMI in cartilage associated with obesity
3) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.36 Pain Relevance 0.17

General Comments

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