INT323909

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
cartilage 2
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 13 99.68 Very High Very High Very High
Inflammation 19 97.40 Very High Very High Very High
Osteoarthritis 94 87.56 High High
cytokine 46 71.68 Quite High
Etanercept 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 97.40 Very High Very High Very High
Osteoarthritis 57 87.56 High High
Toxicity 1 79.60 Quite High
Frailty 40 67.92 Quite High
Hip Osteoarthritis 1 50.00 Quite Low
Obesity 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not clear to what extent the increased levels of IL-6, OSM and lower levels of OPG in conditioned serum may have had a pro-inflammatory effect, but as conditioned serum addition did not result in decreased sulphate incorporation after four days of cartilage explant culture, or a lower PG content after 16 days of culture, conditioning of serum is not likely to have any effect on OA cartilage.
Positive_regulation (increased) of Gene_expression (levels) of OSM in cartilage associated with inflammation and osteoarthritis
1) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.47 Pain Relevance 0.33
DADS is reported to have HDAC inhibitor activity [28] so we measured both the activity of DADS to induce acetylation of histones, and also its ability to repress the IL-1 or IL-1/OSM-induced expression of key MMPs, MMP-1 and -13 (collagen-degrading enzymes) and MMP-3 (an activator of proMMPs) in a model cell line.
Positive_regulation (induced) of Gene_expression (expression) of OSM associated with metalloproteinase
2) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3018463 Disease Relevance 0.20 Pain Relevance 0.28

General Comments

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