INT323949

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.05

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Anatomy Link Frequency brain 2 Rac1 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 1 99.02 Inflammation 10 48.36 agonist 7 5.00 cINOD 6 5.00 Central nervous system 3 5.00 fibrosis 2 5.00 COX-2 inhibitor 1 5.00 cytokine 1 5.00 Nerve growth factor 1 5.00 chemokine 1 5.00

Disease Link Frequency Relevance Heat Adhesions 1 98.26 Disease 50 91.20 Stress 9 71.32 Diabetes Mellitus 10 52.20 Hypertension 1 51.68 INFLAMMATION 10 48.36 Hypertrophy 1 29.08 Targeted Disruption 11 5.60 Cognitive Disorder 5 5.00 Alzheimer's Dementia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

overexpression or activation with ligands can reduce adhesion molecule and matrix metalloproteinase expression and activity in the vasculature, and prevent Rac1 and RhoA activation (Keen et al., 2004; Ramirez et al., 2008; Huang et al., 2009), thus protecting levels of tight junction proteins, and countering leukocyte–endothelial interactions and blood–brain barrier (BBB) compromise that occur in AD (Fiala et al., 2002; Zipser et al., 2007).

Negative_regulation (prevent) of Positive_regulation (activation) of Rac1 in brain associated with metalloproteinase, disease and adhesions

1) Confidence 0.23 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.05

General Comments

This test has worked.