INT323949
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
overexpression or activation with ligands can reduce adhesion molecule and matrix metalloproteinase expression and activity in the vasculature, and prevent Rac1 and RhoA activation (Keen et al., 2004; Ramirez et al., 2008; Huang et al., 2009), thus protecting levels of tight junction proteins, and countering leukocyte–endothelial interactions and blood–brain barrier (BBB) compromise that occur in AD (Fiala et al., 2002; Zipser et al., 2007). | |||||||||||||||
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