INT323949

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
brain 2
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 99.02 Very High Very High Very High
Inflammation 10 48.36 Quite Low
agonist 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 98.26 Very High Very High Very High
Disease 50 91.20 High High
Stress 9 71.32 Quite High
Diabetes Mellitus 10 52.20 Quite High
Hypertension 1 51.68 Quite High
INFLAMMATION 10 48.36 Quite Low
Hypertrophy 1 29.08 Quite Low
Targeted Disruption 11 5.60 Low Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
overexpression or activation with ligands can reduce adhesion molecule and matrix metalloproteinase expression and activity in the vasculature, and prevent Rac1 and RhoA activation (Keen et al., 2004; Ramirez et al., 2008; Huang et al., 2009), thus protecting levels of tight junction proteins, and countering leukocyte–endothelial interactions and blood–brain barrier (BBB) compromise that occur in AD (Fiala et al., 2002; Zipser et al., 2007).
Negative_regulation (prevent) of Positive_regulation (activation) of Rac1 in brain associated with metalloproteinase, disease and adhesions
1) Confidence 0.23 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.05

General Comments

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