INT323980

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.04
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
hypothalamus 2
stomach 2
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nud 100 94.64 High High
Somatostatin 9 88.12 High High
tolerance 4 86.36 High High
sSRI 22 81.16 Quite High
antagonist 38 71.48 Quite High
Cholecystokinin 18 67.96 Quite High
addiction 2 63.48 Quite High
transdermal 2 52.60 Quite High
agonist 21 51.80 Quite High
Central nervous system 2 50.40 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 51 98.76 Very High Very High Very High
Aging 9 97.22 Very High Very High Very High
Dyspepsia 100 94.64 High High
Thyroid Disease 1 93.80 High High
Weight Gain 3 93.12 High High
Obesity 15 89.52 High High
Impaired Glucose Tolerance 5 86.36 High High
Hyperinsulinism 4 85.24 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 77.60 Quite High
Diarrhoea 1 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysregulation of ghrelin secretion and ghrelin resistance in the appetite control system occurred in aged mice and that rikkunshito ameliorated aging-anorexia via inhibition of PDE3.
Regulation (Dysregulation) of Localization (secretion) of ghrelin associated with appetite loss and aging
1) Confidence 0.60 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.90 Pain Relevance 0.04
The data indicated that aging-associated anorexia is caused by an increase in plasma leptin, which results from disturbed reactivity of ghrelin in the hypothalamus and regulation of ghrelin secretion.
Regulation (regulation) of Localization (secretion) of ghrelin in hypothalamus associated with appetite loss and aging
2) Confidence 0.60 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.83 Pain Relevance 0.15
Our results showed that the release of ghrelin was not affected by intragastric pH, whereas the release of des-acyl ghrelin was increased at intragastric pH 2 compared to that at intragastric pH 4 [21].
Neg (not) Regulation (affected) of Localization (release) of ghrelin
3) Confidence 0.40 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0.04
Therefore we investigated the effects of different intragastric pH levels on the release of ghrelin and that of des-acyl ghrelin from the ex vivo perfused rat stomach [21].
Spec (investigated) Regulation (effects) of Localization (release) of ghrelin in stomach
4) Confidence 0.35 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0.04
A possible intracellular mediator of fasting and feeding's reciprocal control of ghrelin secretion is the mammalian target of rapamycin [145], which is suppressed by fasting [145].
Regulation (control) of Localization (secretion) of ghrelin
5) Confidence 0.33 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.45 Pain Relevance 0.18
However, little is known about the influence of duodenal nutrients on ghrelin secretion, warranting further investigation.


Regulation (influence) of Localization (secretion) of ghrelin
6) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912117 Disease Relevance 0.65 Pain Relevance 0.35

General Comments

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