INT323982

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (INPP5E) plasma membrane (INPP5E) cytoskeleton (INPP5E)
cilium (INPP5E) biological_process (INPP5E) lipid metabolic process (INPP5E)
INPP5E (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 42 92.72 High High
Central nervous system 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Visceral pain 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
tricyclic antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 99.96 Very High Very High Very High
Gastroesophageal Reflux Disease 114 99.68 Very High Very High Very High
Acid Reflux 45 98.32 Very High Very High Very High
Bile Reflux 12 93.00 High High
Dyspepsia 15 83.76 Quite High
Esophageal Disease 12 76.72 Quite High
Metaplasia 3 67.08 Quite High
Hypersensitivity 21 45.04 Quite Low
Cough 12 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A temporal relationship was established between symptoms and weakly acidic reflux in 4.1% and 16.7% of patients who were "off" and "on" PPI therapy, respectively.
Gene_expression (therapy) of PPI
1) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.58 Pain Relevance 0
Koek et al48 used combined ambulatory pH and bilirubin absorbance monitoring to assess patients with GERD who were "off" PPI therapy.
Gene_expression (therapy) of PPI associated with gastroesophageal reflux disease
2) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.74 Pain Relevance 0.27
As GERD is the most expensive digestive disease, PPI failure contributes to the increased cost, due to repeated utilization of healthcare resources such as clinic visits, diagnostic tests and prescription medications.7,8
Neg (failure) Gene_expression (failure) of PPI associated with gastroesophageal reflux disease and disease
3) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.95 Pain Relevance 0

General Comments

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