INT323983

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc4) plasma membrane (Trpc4) protein complex (Trpc4)
transmembrane transport (Trpc4) cytoplasm (Trpc4)
Anatomy Link Frequency
smooth muscles 1
Trpc4 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 81 99.76 Very High Very High Very High
TRP channel 2 91.84 High High
antagonist 3 54.88 Quite High
imagery 5 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Overactive Bladder 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was reported that the canonical transient receptor potential channels 4 (TRPC4) and melastatin type transient receptor potential channel 7 (TRPM7) are the molecular candidate for the non-selective cation channels responsible for pacemaker activity in ICC.28 When activation of non-selective cation channels generate net inward current carried predominantly by Na+ under physiological condition, it leads to excitatory effects on GI smooth muscles.29 Although TRPV1 is a non-selective cation channel activated by capsaicin, capsaicin in ICC can modulate TRPC4 or TRPM7 channels with other signaling pathway.
Regulation (modulate) of TRPC4 in smooth muscles associated with qutenza and trp channel
1) Confidence 0.33 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912119 Disease Relevance 0 Pain Relevance 1.12

General Comments

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