INT323984

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 0.66
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm7) plasma membrane (Trpm7) kinase activity (Trpm7)
transmembrane transport (Trpm7) cytoplasm (Trpm7)
Anatomy Link Frequency
smooth muscles 1
neurons 1
brain 1
Trpm7 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 81 99.76 Very High Very High Very High
TRP channel 2 91.84 High High
ischemia 55 87.68 High High
Glutamate 11 79.72 Quite High
Potency 44 78.96 Quite High
Pyramidal cell 33 77.80 Quite High
antagonist 36 54.88 Quite High
imagery 71 41.60 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 33 88.44 High High
Brain Hemorrhage 22 87.92 High High
Cv Unclassified Under Development 33 64.00 Quite High
Death 22 17.52 Low Low
Stress 11 10.28 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Overactive Bladder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations

Concentrations of extracellular divalent cations (Ca2+ and Mg2+) fall substantially during intensive synaptic transmission as well as during some pathophysiological conditions such as epilepsy and brain ischemia.

Regulation (modulation) of TRPM7 in brain associated with brain hemorrhage, epilepsy and ischemia
1) Confidence 0.61 Published 2010 Journal Mol Brain Section Title Doc Link PMC3022637 Disease Relevance 0.18 Pain Relevance 0.04
As NM is a protease inhibitor, we next asked if other linear proteases inhibitors, which share some structural similarity with NM, might modulate TRPM7.
Spec (might) Regulation (modulate) of TRPM7
2) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.06
M) neither blocked the current when co-applied, nor potentiated it when pre-exposed (not shown), indicating not all di-cationic molecules affect TRPM7 current and specific structure of di-cations is required.
Neg (not) Regulation (affect) of TRPM7
3) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
We next tested whether these metabolites mimic NM's effect on TRPM7. p-GBA (up to 1 mM) neither inhibited (through co-application) nor potentiated (pre-exposed application) TRPM7 current (Figure 7B).
Spec (whether) Regulation (effect) of TRPM7
4) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
The stimulating effects of NM on TRPM7 currents are also inversely related to extracellular Ca2+ and Mg2+.
Regulation (effects) of TRPM7
5) Confidence 0.45 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.14 Pain Relevance 0.03
It was reported that the canonical transient receptor potential channels 4 (TRPC4) and melastatin type transient receptor potential channel 7 (TRPM7) are the molecular candidate for the non-selective cation channels responsible for pacemaker activity in ICC.28 When activation of non-selective cation channels generate net inward current carried predominantly by Na+ under physiological condition, it leads to excitatory effects on GI smooth muscles.29 Although TRPV1 is a non-selective cation channel activated by capsaicin, capsaicin in ICC can modulate TRPC4 or TRPM7 channels with other signaling pathway.
Regulation (modulate) of TRPM7 in smooth muscles associated with qutenza and trp channel
6) Confidence 0.35 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912119 Disease Relevance 0 Pain Relevance 1.12
Thus, double-charged termini are not sufficient for modulating the TRPM7 and confirm the typical inner motif of NM is important.
Regulation (modulating) of TRPM7
7) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.03
Here we report that the dications NM, DAPI and HSB function as novel regulators of TRPM7 currents in hippocampal neurons, likely by competing for divalent cations and thereby controlling the entry of Ca2+ and Mg2+.
Regulation (regulators) of TRPM7 in neurons
8) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.06 Pain Relevance 0.03
Their ability to mimic the actions of Ca2+ and Mg2+ in the modulation of TRPM7 suggests that they can bind to the same sites on the underlying channel proteins.
Regulation (modulation) of TRPM7
9) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.03
These results demonstrate that NM, and divalent cations likely compete for regulation of TRPM7 currents.
Regulation (regulation) of TRPM7
10) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07
Netropsin had no effect on TRPM7 currents suggesting the length, the relative overall symmetry or the position of bulky group might be important for TRPM7 modulation.
Spec (might) Regulation (modulation) of TRPM7
11) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.11 Pain Relevance 0.07
Both leupeptin and gabexate are protease inhibitors and do not strongly affect TRPM7 showing that protease inhibitors having a guanidine group do not necessarily modulate TRPM7 currents; although, NM and gabexate inhibit a similar spectrum of serine proteases [33].
Neg (not) Regulation (affect) of TRPM7
12) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.18 Pain Relevance 0.07

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