INT324008

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 2.72 Pain Relevance 0.29

RNA binding (Msi1) nucleus (Msi1) cytoplasm (Msi1)

Anatomy Link Frequency parietal cells 2 stomach 2 colon 1 Msi1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 20 90.32 cINOD 5 64.88 Somatostatin 10 5.00 cytokine 5 5.00 adenocard 5 5.00

Disease Link Frequency Relevance Heat Cancer 20 96.00 Cleidocranial Dysplasia 45 95.72 Metaplasia 185 95.32 Gastritis 10 94.88 Injury 70 90.40 INFLAMMATION 25 90.32 Frailty 10 68.56 Ulcers 200 65.80 Hyperplasia 30 45.04 Peptic Ulcer 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Musashi-1, a marker of progenitor cells in the mouse small intestine, is not expressed in putative progenitor cells, but is found in parietal cells in the rat fundic isthmus[5].

Neg (not) Gene_expression (expressed) of Musashi-1 in parietal cells

1) Confidence 0.13 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.14 Pain Relevance 0.14

DCAMKL1 is coexpressed with Musashi-1 in parietal cells in the mouse stomach[13], whereas this study demonstrated that DCAMKL1 cells were distinct from parietal cells, which express Musashi-1 in the rat stomach[5].

Gene_expression (coexpressed) of Musashi-1 in stomach

2) Confidence 0.13 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.20 Pain Relevance 0

DCAMKL1 is coexpressed with Musashi-1 in parietal cells in the mouse stomach[13], whereas this study demonstrated that DCAMKL1 cells were distinct from parietal cells, which express Musashi-1 in the rat stomach[5].

Gene_expression (express) of Musashi-1 in stomach

3) Confidence 0.12 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.20 Pain Relevance 0

Musashi-1, a marker of progenitor cells in the mouse small intestine, is not expressed in putative progenitor cells, but is found in parietal cells in the rat fundic isthmus[5].

Neg (not) Gene_expression (expressed) of Musashi-1 in parietal cells

4) Confidence 0.12 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.14 Pain Relevance 0.14

After the first report, specific localization of DCAMKL1-expressing cells in a stem cell niche was shown in the small intestine of mice[9,10] and in the colon of mice and humans[11,12], whereas DCAMKL1 was coexpressed with Musashi-1 in parietal cells in the stomach of mice[13].

Gene_expression (coexpressed) of Musashi-1 in colon

5) Confidence 0.10 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.06 Pain Relevance 0

General Comments

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