INT324047

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Lemd3) nucleus (Lemd3) DNA binding (Lemd3)
Anatomy Link Frequency
lamina 1
Lemd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Hereditary Exostoses 40 99.66 Very High Very High Very High
Syndrome 24 99.40 Very High Very High Very High
Osteopoikilosis 104 99.20 Very High Very High Very High
Melorheostosis 48 90.80 High High
Disease 16 84.56 Quite High
Osteogenic Sarcomas 12 82.04 Quite High
Nevus 8 80.84 Quite High
Cancer 12 52.00 Quite High
Synovial Chondromatosis 4 51.28 Quite High
Chondrosarcoma 4 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LEMD3 closely associates with the intranuclear lamina and mutations in other lamin interacting proteins are known to result in the DNA damage accumulation [16].
LEMD3 Binding (associates) of in lamina
1) Confidence 0.48 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2912259 Disease Relevance 0.30 Pain Relevance 0
Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively - coincidence within one family

Background

LEMD3 Binding (mutations) of associated with osteopoikilosis and multiple hereditary exostoses
2) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Title Doc Link PMC2912259 Disease Relevance 1.21 Pain Relevance 0
The patients affected with both LEMD3 and EXT1 gene mutations displayed typical features of the osteopoikilosis.
LEMD3 Binding (affected) of associated with osteopoikilosis
3) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2912259 Disease Relevance 1.53 Pain Relevance 0
This is on one hand necessary for initiation of transcription, and it has been postulated that LEMD3, through BAF and SMAD interactions might regulate the expression of osteogenic genes [2].
LEMD3 Binding (interactions) of
4) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2912259 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox