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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2, Prkaca) mitochondrion (Prkaca) Golgi apparatus (Prkaca)
protein complex (Prkaca) cytoplasm (Prkaca) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 1
Ptger2 (Mus musculus)
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 96.08 Very High Very High Very High
Nerve growth factor 1 91.72 High High
bradykinin 1 90.88 High High
agonist 9 90.04 High High
adenocard 2 89.88 High High
Inflammation 6 87.00 High High
Sciatic nerve 4 79.52 Quite High
unmyelinated 4 78.44 Quite High
tetrodotoxin 3 62.96 Quite High
Neuronal nitric oxide synthase 1 54.48 Quite High
Disease Link Frequency Relevance Heat
Stroke 17 98.28 Very High Very High Very High
Pain 12 96.08 Very High Very High Very High
Neurologic Manifestations 8 93.16 High High
INFLAMMATION 7 87.00 High High
Targeted Disruption 12 86.48 High High
Adhesions 1 59.04 Quite High
Cv General 4 Under Development 3 50.64 Quite High
Cv Unclassified Under Development 4 42.08 Quite Low
Brain Hemorrhage 3 10.52 Low Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports have shown that the EP2 receptor elicits neuroprotective effects under conditions of excitotoxicity and oxygen-glucose deprivation by increasing intracellular levels of cAMP and activating PKA signaling [9,10].
EP2 receptor Positive_regulation (activating) of PKA
1) Confidence 0.24 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.39 Pain Relevance 0.10
Among these compounds, PGE2, a derivate of arachidonic acid, binds to its receptors, EP2 and EP4, which in turn activate intracellular Protein kinase A (PKA) (reviewed in Refs. [31,25]).
EP2 Positive_regulation (activate) of PKA in PGE2
2) Confidence 0.03 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.24 Pain Relevance 0.51

General Comments

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