INT324068

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 32
Disease Relevance 28.19
Pain Relevance 40.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (GCH1, SNRNP70) nucleoplasm (SNRNP70) small molecule metabolic process (GCH1)
protein complex assembly (GCH1) protein complex (GCH1) cytoplasm (GCH1)
Anatomy Link Frequency
teeth 2
GCH1 (Homo sapiens)
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 960 100.00 Very High Very High Very High
Pain 2240 99.76 Very High Very High Very High
analgesia 832 99.04 Very High Very High Very High
Chronic pancreatitis 32 97.48 Very High Very High Very High
backache 32 94.84 High High
opioid receptor 64 89.64 High High
painful pain 32 88.12 High High
pain labor 96 86.72 High High
tolerance 32 81.68 Quite High
Tetrahydrobiopterin 160 80.48 Quite High
Disease Link Frequency Relevance Heat
Pain 2208 99.76 Very High Very High Very High
Pancreatitis 32 97.48 Very High Very High Very High
Low Back Pain 32 94.84 High High
Fetal Death 32 92.20 High High
Nociception 128 88.12 High High
Neuropathic Pain 96 86.96 High High
Labor Pain 96 86.72 High High
Genetic Predisposition To Disease 64 75.76 Quite High
Inflammatory Pain 32 43.88 Quite Low
Sprains And Strains 32 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pain behavior related outcomes for homozygous carriers, heterozygous carriers and non-carriers of the pain-protective SNP combination of GCH1 are given in Table 2.
GCH1 Binding (combination) of SNP associated with pain and gch1
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.76 Pain Relevance 1.13
Further studies on the pain-protective SNP combination of GCH1 have been more discouraging.
GCH1 Binding (combination) of SNP associated with pain and gch1
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 1.62 Pain Relevance 1.75
Genetic polymorphisms that are of importance for regulation of pain during labor are scarcely studied and the importance of the pain-protective SNP combination of GCH1 in laboring women is unknown.
GCH1 Binding (combination) of SNP associated with pain and gch1
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.90 Pain Relevance 1.61
Given that we only found signs of altered pain sensitivity among homozygous carriers of the pain-protective SNP combination of GCH1, the major limitation of our study is the number of women included.
GCH1 Binding (combination) of SNP associated with pain and gch1
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 1.08 Pain Relevance 1.37
Even though carriers of the pain-protective SNP combination of GCH1 in previous studies have been shown to be less sensitive to pain, the major finding of the present study was that this specific pain-protective SNP combination did not dramatically change pain perception or behavior during labor.
GCH1 Binding (combination) of SNP associated with pain and gch1
5) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.68 Pain Relevance 1.26
Pain behavior related outcomes for homozygous carriers, heterozygous carriers and non-carriers of the pain-protective SNP combination of GCH1 are given in Table 2.
GCH1 Binding (combination) of SNP associated with pain and gch1
6) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.76 Pain Relevance 1.13
Homozygous carriers of the pain-protective SNP combination of GCH1 comprised only 2.2% of the population-based sample but appeared to arrive in the delivery ward with a more advanced stage of cervical dilation than heterozygous and non-carriers did.
GCH1 Binding (combination) of SNP associated with pain and gch1
7) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.96 Pain Relevance 1.48
Homozygous carriers of the pain-protective SNP combination of GCH1 arrived to the delivery ward with a more advanced stage of cervical dilation compared to heterozygous carriers and non-carriers.
GCH1 Binding (combination) of SNP associated with pain and gch1
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2912270 Disease Relevance 0.36 Pain Relevance 0.74
Even though carriers of the pain-protective SNP combination of GCH1 in previous studies have been shown to be less sensitive to pain, the major finding of the present study was that this specific pain-protective SNP combination did not dramatically change pain perception or behavior during labor.
GCH1 Binding (combination) of SNP associated with pain and gch1
9) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.68 Pain Relevance 1.26
Among the 676 Caucasian subjects who had complete data on the SNP analyses in the study population, 15 (2.2%) were homozygous carriers, 180 (26.6%) heterozygous carriers and 481 (71.1%) were non-carriers of the pain-protective SNP combination of GCH1.
GCH1 Binding (combination) of SNP associated with pain and gch1
10) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.80 Pain Relevance 1.03
Among the 676 Caucasian subjects who had complete data on the SNP analyses in the study population, 15 (2.2%) were homozygous carriers, 180 (26.6%) heterozygous carriers and 481 (71.1%) were non-carriers of the pain-protective SNP combination of GCH1.
GCH1 Binding (combination) of SNP associated with pain and gch1
11) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.80 Pain Relevance 1.03
A possible association between the pain-protective SNP combination of GCH1 and use of second line analgesia was suggested by the bivariate analysis (p = 0.10).
GCH1 Binding (combination) of SNP associated with pain, gch1 and analgesia
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.64 Pain Relevance 1.32
Genotyping was performed and three single nucleotide polymorphisms (SNP) previously defined as a pain-protective SNP combination of GCH1 were used.


GCH1 Binding (combination) of SNP associated with pain and gch1
13) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2912270 Disease Relevance 0.36 Pain Relevance 0.73
Homozygous carriers of the pain-protective SNP combination of GCH1 arrived to the delivery ward with a more advanced stage of cervical dilation compared to heterozygous carriers and non-carriers.
GCH1 Binding (combination) of SNP associated with pain and gch1
14) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2912270 Disease Relevance 0.36 Pain Relevance 0.74
Homozygous carriers of the pain-protective SNP combination of GCH1 comprised only 2.2% of the population-based sample but appeared to arrive in the delivery ward with a more advanced stage of cervical dilation than heterozygous and non-carriers did.
GCH1 Binding (combination) of SNP associated with pain and gch1
15) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.96 Pain Relevance 1.48
Genotyping of the pain-protective SNP combination of GCH1
GCH1 Binding (combination) of SNP associated with pain and gch1
16) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.83 Pain Relevance 1.01
Given that we only found signs of altered pain sensitivity among homozygous carriers of the pain-protective SNP combination of GCH1, the major limitation of our study is the number of women included.
GCH1 Binding (combination) of SNP associated with pain and gch1
17) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 1.08 Pain Relevance 1.37
Kim and colleagues [16] found no association between rated pain severity after surgical removal of molar teeth and the pain-protective SNP combination of GCH1, and similar negative findings were obtained in patients with chronic pancreatitis [17].
GCH1 Binding (combination) of SNP in teeth associated with pain, gch1 and chronic pancreatitis
18) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 1.60 Pain Relevance 1.80
There is a known ethnic difference in pain sensitivity and genotype frequencies of the pain-protective SNP combination of GCH1 [16].
GCH1 Binding (combination) of SNP associated with pain and gch1
19) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 1.01 Pain Relevance 1.37
Heterozygous carriers of the pain-protective SNP combination of GCH1 did not differ in any aspect from non-carriers in the possible pain behavior related outcomes of the study.
GCH1 Binding (combination) of SNP associated with pain and gch1
20) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.85 Pain Relevance 1.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox