INT324128

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd4, Cd40) enzyme binding (Cd4, Cd40) extracellular space (Cd40)
extracellular region (Cd40) cell adhesion (Cd4)
Anatomy Link Frequency
monocytes 1
T cells 1
Cd4 (Mus musculus)
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 68.32 Quite High
tolerance 15 65.76 Quite High
Inflammation 13 62.16 Quite High
cytokine 10 44.64 Quite Low
chemokine 1 43.60 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 68.32 Quite High
INFLAMMATION 13 62.16 Quite High
Disease 16 61.12 Quite High
Autoimmune Disease 17 59.04 Quite High
Infection 15 53.60 Quite High
Hyperglycemia 4 48.96 Quite Low
Mixed Connective Tissue Disorder 14 48.68 Quite Low
Viral Infection 4 47.04 Quite Low
Diabetes Mellitus 14 22.64 Low Low
Influenza Virus Infection 13 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding may seem unexpected, since this surface marker on CD4 + T cells is known to interact with CD40 on antigen-presenting cells, found by us to become strongly up-regulated on monocytes [19].
CD4 Binding (interact) of CD40 in monocytes
1) Confidence 0.29 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.25 Pain Relevance 0.07
However, the finding that IL-2 deficient mice are able to mount primary CD8+ T cell responses and that CD4+ T cells condition DC, through CD40L/CD40 interactions, to efficiently prime CD8+ T cells disfavored the original hypothesis [33], [34], [35], [45].
CD4 Binding (interactions) of CD40 in T cells
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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