INT32418

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.93
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NCS1) Golgi apparatus (NCS1) plasma membrane (NCS1)
cytoplasm (NCS1)
Anatomy Link Frequency
blood 2
caudate nucleus 2
neck 1
colon 1
autonomic 1
NCS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 88 90.68 High High
medulla 296 90.16 High High
vagus nerve 24 85.36 High High
depression 32 75.48 Quite High
Rostral ventrolateral medulla 8 71.80 Quite High
aspirin 8 63.76 Quite High
Inflammation 14 50.00 Quite Low
cva 32 44.04 Quite Low
Central grey 8 42.52 Quite Low
withdrawal 8 30.44 Quite Low
Disease Link Frequency Relevance Heat
Syncope 552 100.00 Very High Very High Very High
Anxiety Disorder 272 100.00 Very High Very High Very High
Asthma 82 100.00 Very High Very High Very High
Convulsion 8 99.92 Very High Very High Very High
Congenital Anomalies 24 99.48 Very High Very High Very High
Hypoxia 8 99.44 Very High Very High Very High
Overactive Bladder 16 99.28 Very High Very High Very High
Colon Cancer 4 99.16 Very High Very High Very High
Injury 32 99.00 Very High Very High Very High
Stress 32 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also relevant are the frequency and circumstances of faints including other triggers; NCS is not associated with defecation, urination, coughing, swallowing or other neck movements.
NCS Binding (associated) of in neck associated with overactive bladder
1) Confidence 0.40 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 1.03 Pain Relevance 0.04
Although NCS is not associated with lower caudate volumes (we found no significant difference between NCS and control groups), our morphometric findings suggest that the caudate nucleus supports the modulatory influence of anxiety state on frequency of syncope in NCS, via a contribution to autonomic cardiovascular regulation.
NCS Binding (associated) of in autonomic associated with anxiety disorder and syncope
2) Confidence 0.40 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 1.17 Pain Relevance 0.05
Notably, people with NCS demonstrate abnormalities in cerebral autoregulation, where active cerebral vasoconstriction occurs in response to low systemic blood pressure (e.g.
NCS Binding (people) of in blood associated with congenital anomalies and increased venous pressure under development
3) Confidence 0.31 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.57 Pain Relevance 0.19
Further, we found that subregional volumes within the left caudate nucleus were significantly negatively correlated with fainting frequency and resting heart rate variability measures in people with NCS, and with anxiety levels (in both NCS and controls).
NCS Binding (people) of in caudate nucleus associated with anxiety disorder and syncope
4) Confidence 0.31 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.85 Pain Relevance 0.18
Further, we found that subregional volumes within the left caudate nucleus were significantly negatively correlated with fainting frequency and resting heart rate variability measures in people with NCS, and with anxiety levels (in both NCS and controls).
NCS Binding (people) of in caudate nucleus associated with anxiety disorder and syncope
5) Confidence 0.31 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.83 Pain Relevance 0.18
NCS is associated with emotional triggers, anxiety states and stress.
NCS Binding (associated) of associated with stress and anxiety disorder
6) Confidence 0.30 Published 2009 Journal Neuroimage Section Abstract Doc Link PMC2726440 Disease Relevance 0.82 Pain Relevance 0
NCS is distinguishable from other forms of syncope by this relatively early onset, by a higher proportion of females, a generally benign course and, most characteristically, by its association with specific ‘emotional’ triggers that include social challenge in people with social anxiety and the sight of blood or penetrative injury in people with blood phobia (Mathias et al., 2001).
NCS Binding (association) of in blood associated with phobia, injury, anxiety disorder and syncope
7) Confidence 0.30 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 1.18 Pain Relevance 0.03
Associations between brain morphometry (regional gray and white matter volumes) and NCS, resting physiology and anxiety were tested using voxel-based morphometry (VBM).
NCS Binding (Associations) of in white matter associated with anxiety disorder
8) Confidence 0.30 Published 2009 Journal Neuroimage Section Abstract Doc Link PMC2726440 Disease Relevance 0.97 Pain Relevance 0.12
For targeting chemotherapy of colorectal carcinoma, mitomycin C (MMC) and neocarzinostatin (NCS) were covalently bound to monoclonal antibody A7 which is highly specific to human colon cancer.
NCS Binding (bound) of in colon associated with colon cancer
9) Confidence 0.25 Published 1987 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 2952068 Disease Relevance 0.52 Pain Relevance 0
We evaluated the associations of three genetic polymorphisms of IL-13 with AIA, ATA, and NCs in a Korean population.
NCs Binding (associations) of associated with asthma
10) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.00 Pain Relevance 0.03

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