INT32421

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Context Info
Confidence 0.73
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 17.23
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCER2) plasma membrane (FCER2)
Anatomy Link Frequency
Plasma cell 2
granulocytes 1
lymphocytes 1
bands 1
FCER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 99.92 Very High Very High Very High
cytokine 53 99.26 Very High Very High Very High
Pain 7 98.68 Very High Very High Very High
alcohol 1 97.12 Very High Very High Very High
cINOD 5 95.52 Very High Very High Very High
Paracetamol 2 95.44 Very High Very High Very High
corticosteroid 14 94.56 High High
aspirin 9 93.88 High High
abdominal pain 1 90.88 High High
Inflammatory response 3 87.04 High High
Disease Link Frequency Relevance Heat
Multiple Myeloma 8 99.98 Very High Very High Very High
Diffuse Large B-cell Lymphoma 4 99.98 Very High Very High Very High
Cancer 37 99.80 Very High Very High Very High
Hypergammaglobulinemia 2 99.76 Very High Very High Very High
INFLAMMATION 74 99.52 Very High Very High Very High
Necrosis 1 99.52 Very High Very High Very High
Hypersensitivity 64 99.44 Very High Very High Very High
Pain 6 98.68 Very High Very High Very High
Autoimmune Disease 6 98.66 Very High Very High Very High
Epstein-barr Virus 15 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific immunoglobulin E were negative in all cases.
Neg (negative) Gene_expression (negative) of immunoglobulin E
1) Confidence 0.73 Published 2005 Journal Contact Derm. Section Abstract Doc Link 15932579 Disease Relevance 0.42 Pain Relevance 0.08
This effect correlated with the inhibition of IL-4-induced CD23 expression.
Gene_expression (expression) of CD23
2) Confidence 0.51 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801685 Disease Relevance 0.61 Pain Relevance 0.26
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expressed) of CD23 associated with diffuse large b-cell lymphoma
3) Confidence 0.49 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.76 Pain Relevance 0.11
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expression) of CD23 associated with diffuse large b-cell lymphoma
4) Confidence 0.42 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.75 Pain Relevance 0.11
Pathogenetic links between the two diseases are presented: (1) deposition of circulating immune complexes in the vessel wall; (2) adjuvant activity with cross reaction between parasitic antigen and human vessel wall; (3) immunoglobulin E (IgE) aggregates and soluble antigen IgE complexes precipitation in vessel wall; and (4) hypereosinophilia-induced tissue damage.
Gene_expression (precipitation) of immunoglobulin E associated with disease
5) Confidence 0.39 Published 1981 Journal Am. J. Med. Section Abstract Doc Link 6114636 Disease Relevance 2.05 Pain Relevance 0.08
The production of an anti-Fc epsilon R2 monoclonal antibody has allowed the identification on platelet membrane preparations of two major bands of 43-45 and 31 kD.
Gene_expression (production) of Fc epsilon R2 in bands
6) Confidence 0.38 Published 1987 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2952599 Disease Relevance 0.54 Pain Relevance 0.09
RIII and CD23/Fc?
Gene_expression (/) of CD23
7) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.33 Pain Relevance 0
The tumor cells were immunonegative for CD3, CD5, cyclin D1, CD21, CD23, CD10, and Ig M.
Gene_expression (immunonegative) of CD23 associated with cancer
8) Confidence 0.24 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.85 Pain Relevance 0
The lymphocytes express B-cell markers (CD19, CD20, and CD79a) and are negative for CD3, CD5, CD10, CD23, and cyclin D1.
Neg (negative) Gene_expression (negative) of CD23 in lymphocytes
9) Confidence 0.21 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.48 Pain Relevance 0.26
The low affinity receptor (Fc?
Gene_expression (The) of low affinity receptor
10) Confidence 0.18 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.48 Pain Relevance 0.08
The importance of identifying underlying causative factors and the recent introduction of novel therapeutic approaches, including the targeting of immunoglobulin E and tumour necrosis factor alpha with biological agents, emphasise the need for careful phenotyping of patients with severe disease to target improved management of the individual patient's needs.
Gene_expression (targeting) of immunoglobulin E associated with necrosis, cancer and disease
11) Confidence 0.08 Published 2006 Journal Lancet Section Abstract Doc Link 16935689 Disease Relevance 1.09 Pain Relevance 0.22
An immediate allergic response (type I hypersensitivity, as opposed to delayed-type, cell-mediated allergic reactions) includes the preferential synthesis and secretion of immunoglobulin E (IgE) molecules, which subsequently anchor efficiently to high-affinity receptors on tissue mast cells and basophilic granulocytes.
Gene_expression (synthesis) of immunoglobulin E in granulocytes associated with hypersensitivity
12) Confidence 0.07 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 1.23 Pain Relevance 0.17
Immunoglobulin E antibodies to all four proteinases were found in most of the 12 sera, but in varying proportions.
Gene_expression (found) of Immunoglobulin E
13) Confidence 0.06 Published 1995 Journal Spine Section Body Doc Link 7631245 Disease Relevance 0 Pain Relevance 0
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Gene_expression (production) of immunoglobulin E associated with cytokine
14) Confidence 0.04 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.68 Pain Relevance 0.27
These children will frequently have elevated levels of Immunoglobulin E (IgE).
Gene_expression (levels) of Immunoglobulin E
15) Confidence 0.01 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2891801 Disease Relevance 2.09 Pain Relevance 0.26
Specific immunoglobulin E determination was negative for food and drug allergens, C3 and C4 were in the normal range, C1 inhibitor was slightly reduced and serum tryptase was undetectable.
Gene_expression (undetectable) of immunoglobulin E
16) Confidence 0.01 Published 2007 Journal J Investig Allergol Clin Immunol Section Abstract Doc Link 17460952 Disease Relevance 0.67 Pain Relevance 0.26
Plasma cell leukemia producing monoclonal immunoglobulin E.
Gene_expression (producing) of monoclonal immunoglobulin E in Plasma cell associated with multiple myeloma
17) Confidence 0.01 Published 2009 Journal Int. J. Hematol. Section Title Doc Link 19728026 Disease Relevance 0.68 Pain Relevance 0.17
A 78-year-old male with lumbar pain and dim consciousness presented the clinical pictures of plasma cell leukemia (PCL) producing a large amount of monoclonal immunoglobulin E (IgE)/kappa protein.
Gene_expression (producing) of monoclonal immunoglobulin E in plasma cell associated with pain and multiple myeloma
18) Confidence 0.01 Published 2009 Journal Int. J. Hematol. Section Abstract Doc Link 19728026 Disease Relevance 0.54 Pain Relevance 0.10
The cause of this allergic angiitis and granulomatosis is not known, but autoimmunity is evident with the presence of hypergammaglobulinemia, increased levels of immunoglobulin E (IgE), and perinuclear-staining (p)-ANCA.
Gene_expression (levels) of immunoglobulin E associated with hypergammaglobulinemia, autoimmune disease and hypersensitivity vasculitis
19) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.98 Pain Relevance 0.04

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