INT32432

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.72
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
caudate nucleus 2
putamen 2
striatum 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 188 100.00 Very High Very High Very High
gABA 11 100.00 Very High Very High Very High
Enkephalin 18 99.80 Very High Very High Very High
substance P 10 98.96 Very High Very High Very High
Dynorphin 9 98.64 Very High Very High Very High
agonist 9 98.16 Very High Very High Very High
anesthesia 1 97.34 Very High Very High Very High
positron emission tomography 7 95.38 Very High Very High Very High
opioid receptor 22 90.96 High High
imagery 5 85.76 High High
Disease Link Frequency Relevance Heat
Lifespan 2 99.60 Very High Very High Very High
Targeted Disruption 37 98.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 77 94.00 High High
Dyskinesias 3 92.96 High High
Disease 20 92.44 High High
Retts Disease 7 88.88 High High
Hypokinesia 2 85.00 Quite High
Tremor 3 84.36 Quite High
Cognitive Disorder 6 84.16 Quite High
Neurodegenerative Disease 1 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same effects were produced by the direct injection of dopamine or its agonists into the dorsomedial part of caudate nucleus ipsilateral to the lesion, where spiroperidol binding to the D2 receptor was increased in the affinity.
Positive_regulation (increased) of D2 receptor Binding (binding) of in caudate nucleus associated with dopamine and agonist
1) Confidence 0.67 Published 1987 Journal Eur. Neurol. Section Abstract Doc Link 2953603 Disease Relevance 0.50 Pain Relevance 0.35
Rats who undergo endurance training show increased
   D2 receptor binding over the lifespan compared to control animals, suggesting that endurance
   training provides some protection from age related loss of D2 receptor functioning 97. 
Positive_regulation (increased) of D2 Binding (binding) of associated with lifespan
2) Confidence 0.60 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.51 Pain Relevance 0.20
D2 receptor ligand binding was increased in wild-type mice and exhibited a biphasic change, with a decrease at 0.625 and 2.5 mg/kg doses of METH and an increase with 10 mg/kg of METH, in mu-OR knockout mice.
Positive_regulation (increased) of D2 receptor Binding (binding) of associated with targeted disruption
3) Confidence 0.29 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17139685 Disease Relevance 0.44 Pain Relevance 0.63
D1(-/-)D3(-/-) mice evidenced decreased dynorphin and substance P but normal enkephalin expression, whereas dopamine D2-like and GABA(A) receptor binding were increased.
Positive_regulation (increased) of D2 Binding (binding) of associated with gaba, dopamine, dynorphin, enkephalin and substance p
4) Confidence 0.13 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.30 Pain Relevance 1.45
Upregulated dopamine D2-like binding and enkephalin in D1(-/-) mice may be due to decreased dopamine turnover.
Positive_regulation (Upregulated) of D2 Binding (binding) of associated with dopamine and enkephalin
5) Confidence 0.12 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.28 Pain Relevance 1.42
This idea fits with evidence that mice lacking the Oprm1 gene show increased DA D2 receptor binding in the striatum and increased activity levels when the receptor is stimulated [42].
Positive_regulation (how incre) of DA D2 receptor Binding (tor bin) of in striatum associated with dopamine
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.30 Pain Relevance 0.56
PET scans with [(11)C] raclopride and with [(18)F] 6-fluorodopa under intravenous propofol anesthesia showed the mean uptake of fluorodopa to be reduced by 13.1% in caudate and by 12.4% in putamen as compared to the controls, whereas dopamine D2 receptor binding, as indicated by raclopride binding, was significantly increased by 9.7% in caudate and by 9.6% in putamen.
Positive_regulation (increased) of dopamine D2 receptor Binding (binding) of in putamen associated with dopamine, anesthesia and positron emission tomography
7) Confidence 0.07 Published 2001 Journal Brain Dev. Section Abstract Doc Link 11738851 Disease Relevance 0.39 Pain Relevance 0.58

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