INT324332

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.07
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (UMOD) extracellular region (UMOD) Golgi apparatus (UMOD)
plasma membrane (UMOD)
Anatomy Link Frequency
kidney 3
UMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 37 92.48 High High
Inflammation 37 86.92 High High
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Migraine 6 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Restless leg syndrome 6 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 5 100.00 Very High Very High Very High
Chronic Renal Failure 294 99.76 Very High Very High Very High
Kidney Stones 114 98.68 Very High Very High Very High
Aging 30 97.36 Very High Very High Very High
Disease 123 97.12 Very High Very High Very High
Prostate Or Kidney Disorder 54 94.84 High High
Hypertension 126 93.88 High High
Diabetes Mellitus 96 93.20 High High
Mucocutaneous Lymph Node Syndrome 50 93.00 High High
Arthritis 34 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar interaction between the UMOD variant, age and CKD was also observed when the association analysis for CKD was stratified by year of birth used here as a proxy for age of onset (Table 1).
UMOD variant Binding (interaction) of associated with chronic renal failure
1) Confidence 0.41 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.61 Pain Relevance 0
Recently, Köttgen et al. [14] published the first genome-wide association study (GWAS) on eGFRcrea, eGFR based on cystatin C (eGFRcys), another measure of kidney function, and CKD, reporting significant association with eGFRcrea at three loci (UMOD, SHROOM3 (GeneID: 57619) and GATM-SPATA5L1 (GeneIDs: 2628 and 79029)), with eGFRcys at two loci (CST3-CST9 (GeneIDs: 1471 and 128822) and STC1 (GeneID: 6781)) and with CKD at one locus (UMOD) [14].
UMOD Binding (association) of in kidney associated with chronic renal failure
2) Confidence 0.35 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 1.40 Pain Relevance 0
Association of the UMOD variant with serum urea
UMOD variant Binding (Association) of
3) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.40 Pain Relevance 0
In contrast to the UMOD variant, we did not observe an interaction between the variants at these other loci and age.
UMOD variant Binding (interaction) of
4) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.36 Pain Relevance 0
Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases

Chronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality.

UMOD Binding (Association) of in Kidney associated with chronic renal failure, disease and kidney stones
5) Confidence 0.30 Published 2010 Journal PLoS Genetics Section Title Doc Link PMC2912386 Disease Relevance 0.83 Pain Relevance 0
We also demonstrate for the first time an interaction between the UMOD variant and age that suggests that this variant may adversely affect the aging kidney and its adaptation to age-related risk factors of kidney disease, such as hypertension and diabetes.
UMOD variant Binding (interaction) of in kidney associated with prostate or kidney disorder, aging, diabetes mellitus and hypertension
6) Confidence 0.30 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2912386 Disease Relevance 1.90 Pain Relevance 0.04
As shown in Tables 6 and 7, the 17-peptide biomarkers were found to be degradation products of eight different proteins: alpha1 antitrypsin (A1AT, two peptides having overlapping sequences), collagen type I alpha 1 (COL1A1; five peptides and three of them having overlapping sequences), collagen type I alpha 2 (COL1A2; one peptide), collagen type III alpha 1 (COL3A1; one peptide), collagen type IX alpha 2 (COL9A2; one peptide), fibrinogen alpha (FGA; two peptides having overlapping sequences), fibrinogen beta (FGB; two peptides having overlapping sequences), and uromodulin (UMOD; three peptides having overlapping sequences).
uromodulin Binding (shown) of associated with alpha-1-antitrypsin deficiency
7) Confidence 0.30 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 1.57 Pain Relevance 0.30

General Comments

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