INT3244

Context Info Confidence 0.03 First Reported 1976 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 37 Total Number 38 Disease Relevance 16.69 Pain Relevance 12.61

Anatomy Link Frequency blood 31 smooth muscle 1 CSF 1 CeA 1 central nervous system 1 eCB (Mus musculus)

Pain Link Frequency Relevance Heat cva 68 100.00 depression 9 100.00 Dopamine 6 100.00 Migraine 7 99.88 ischemia 6 99.84 isoflurane 34 99.68 antagonist 12 99.68 orphanin 6 99.58 cINOD 8 99.52 opiate 4 99.44

Disease Link Frequency Relevance Heat Cv General 3 Under Development 25 100.00 Depression 8 100.00 Epilepsy 7 99.98 Headache 7 99.88 Hypertension 5 99.88 Cv General 4 Under Development 26 99.84 Hypocapnia 14 99.56 Premature Birth 1 99.48 Attention Deficit Hyperactivity Disorder 3 99.44 Pressure And Volume Under Development 7 99.36

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Concomitantly, B-HT 920 reduced the total cerebral blood flow (CBF) by 23%.

Negative_regulation (reduced) of cerebral blood flow in blood

1) Confidence 0.03 Published 1986 Journal Curr. Eye Res. Section Abstract Doc Link 3757544 Disease Relevance 0.24 Pain Relevance 0

Unrestricted use of oxygen in the delivery room after preterm birth has been associated with reduced cerebral blood flow (CBF) 2 h later.

Negative_regulation (reduced) of cerebral blood flow in blood associated with premature birth

2) Confidence 0.03 Published 2004 Journal Pediatr. Res. Section Abstract Doc Link 14681497 Disease Relevance 0.34 Pain Relevance 0.09

A reduction in cerebral blood flow (CBF), mimicking that seen during the aura and headache phase of migraine, is typically observed following SD in the rat.

Negative_regulation (reduction) of cerebral blood flow in blood associated with epilepsy, depression, migraine and headache

3) Confidence 0.03 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933284 Disease Relevance 0.95 Pain Relevance 0.62

A significant reduction in intracranial pressure, cerebral blood flow and metabolism at 1 min was found to have essentially subsided 20 min after the injection.

Negative_regulation (reduction) of cerebral blood flow in blood associated with cva

4) Confidence 0.01 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 676645 Disease Relevance 0.17 Pain Relevance 0.18

While neuronal numbers, dendrites and synapses decline with age and the ventricular volume triples, cerebral circulation is similar to young adults, although there is a reduction in cerebral blood flow (CBF).

Negative_regulation (reduction) of cerebral blood flow in blood

5) Confidence 0.01 Published 2004 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 15334329 Disease Relevance 0.33 Pain Relevance 0.36

Longitudinal 123I-IMP SPECT (autoradiography method) findings demonstrated diffuse cerebral blood flow (CBF) decrease and relative hyperactivity in the lower frontal lobe.

Negative_regulation (decrease) of cerebral blood flow in lobe associated with attention deficit hyperactivity disorder

6) Confidence 0.01 Published 2000 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 11144150 Disease Relevance 0.66 Pain Relevance 0.20

A variety of mechanisms may be responsible for the neurological dysfunction: current evidence indicates that most of these mechanisms produce a reduction in cerebral blood flow (CBF).

Negative_regulation (reduction) of cerebral blood flow in blood associated with anesthesia

7) Confidence 0.00 Published 1988 Journal Acta Neurochir Suppl (Wien) Section Abstract Doc Link 3066143 Disease Relevance 1.32 Pain Relevance 0.38

Both measures reduce cerebral blood flow (CBF).

Negative_regulation (reduce) of cerebral blood flow in blood

8) Confidence 0.00 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 3932610 Disease Relevance 0.71 Pain Relevance 0.15

Xenon-computed tomography (CT) disclosed gross reduction in the cerebral blood flow (CBF) of the left occipital area.

Negative_regulation (reduction) of cerebral blood flow in blood

9) Confidence 0.00 Published 2008 Journal Mov. Disord. Section Abstract Doc Link 18067174 Disease Relevance 0.50 Pain Relevance 0.21

The late spasm is associated with a generalized reduction in cerebral blood flow (CBF) of about 30%.

Negative_regulation (reduction) of cerebral blood flow in blood associated with muscular spasm

10) Confidence 0.00 Published 1993 Journal Acta Neurochir (Wien) Section Abstract Doc Link 7687406 Disease Relevance 0.64 Pain Relevance 0.40

Fentanyl (25 and 100 micrograms/kg iv) produced dose dependent depression of cerebral blood flow (CBF), measured by radioactive microspheres, and cerebral oxygen consumption (CMRO2).

Negative_regulation (depression) of cerebral blood flow in blood associated with depression

11) Confidence 0.00 Published 1985 Journal Life Sci. Section Abstract Doc Link 3999926 Disease Relevance 0.10 Pain Relevance 0.68

During normoxic conditions, cocaine administration (1.5 mg/kg i.v.), resulting in peak plasma cocaine levels on the order of 10(-6) M, decreased cerebral blood flow (CBF) by 14%, as measured by the tracer microsphere method.

Negative_regulation (decreased) of cerebral blood flow in blood associated with cocaine

12) Confidence 0.00 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8122291 Disease Relevance 0.34 Pain Relevance 0.50

This was accompanied by a significant 21% reduction in cerebral metabolic rate for oxygen (CMRO2) and a 15% reduction in cerebral blood flow (CBF).

Negative_regulation (reduction) of cerebral blood flow in blood

13) Confidence 0.00 Published 1986 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3090846 Disease Relevance 0 Pain Relevance 0.22

These results suggest cerebral blood flow (CBF) reduction after both inductions but by a different mechanism.

Negative_regulation (reduction) of cerebral blood flow in blood

14) Confidence 0.00 Published 1989 Journal Dev Pharmacol Ther Section Abstract Doc Link 2612299 Disease Relevance 0 Pain Relevance 0.31

We assessed cerebrovascular responsivity to changes in arterial carbon dioxide tension (PaCO2) during 3 h of 1 MAC isoflurane anesthesia to determine whether it parallels previously reported time-dependent decrease in normocapnic cerebral blood flow (CBF).

Spec (whether) Negative_regulation (decrease) of cerebral blood flow in blood associated with anesthesia and isoflurane

15) Confidence 0.00 Published 1991 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815378 Disease Relevance 0.41 Pain Relevance 0.57

Barbiturates decrease both cerebral metabolic rate (CMR) and cerebral blood flow (CBF) and thereby preserve CBF and CMR coupling.

Negative_regulation (decrease) of cerebral blood flow in blood

16) Confidence 0.00 Published 1981 Journal Anesthesiology Section Abstract Doc Link 6271025 Disease Relevance 0 Pain Relevance 0.28

These techniques include infusion of mannitol, lumbar cerebrospinal fluid (CSF) drainage, administration of anaesthetic agents known to decrease cerebral blood flow (CBF) and hypocapnia.

Negative_regulation (decrease) of cerebral blood flow in CSF associated with hypocapnia

17) Confidence 0.00 Published 1994 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7818206 Disease Relevance 1.24 Pain Relevance 0.23

The purpose of our study was to investigate the fact that, during aneurysmal surgery, the degree of reduced cerebral blood flow (CBF) and disturbed CO2 responsiveness due to subarachnoid hemorrhage (SAH) were influenced by the elapse of time from SAH to surgery.

Negative_regulation (reduced) of cerebral blood flow in blood associated with cv general 4 under development and cva

18) Confidence 0.00 Published 1989 Journal No Shinkei Geka Section Abstract Doc Link 2506480 Disease Relevance 0.57 Pain Relevance 0.28

In the absence of any significant increase in ICP, cerebral edema appears to cause a significant reduction in cerebral blood flow and this reduction corresponds with the magnitude and location of the edema.

Negative_regulation (reduction) of cerebral blood flow in blood associated with pressure and volume under development and cva

19) Confidence 0.00 Published 1976 Journal Stroke Section Abstract Doc Link 1258101 Disease Relevance 0.87 Pain Relevance 0.35

Cerebral blood flow (CBF) was reduced during normotension by FPI, further reduced by hypotension, but both were partially protected by MK801 in the newborn.

Negative_regulation (reduced) of Cerebral blood flow in blood associated with hypotension and brain injury

20) Confidence 0.00 Published 2004 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 15581278 Disease Relevance 1.43 Pain Relevance 0.29

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