INT32446

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Context Info
Confidence 0.68
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.31
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
brain 2
spinal cord 1
cleavage 1
bands 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 29 100.00 Very High Very High Very High
bradykinin 17 99.96 Very High Very High Very High
Enkephalin 28 99.80 Very High Very High Very High
qutenza 2 99.40 Very High Very High Very High
spinal inflammation 6 98.50 Very High Very High Very High
Spinal cord 3 98.16 Very High Very High Very High
Deafferentation 1 95.84 Very High Very High Very High
dorsal rhizotomy 2 95.16 Very High Very High Very High
Neuropeptide 3 95.04 Very High Very High Very High
Catecholamine 1 90.68 High High
Disease Link Frequency Relevance Heat
Fever 5 99.12 Very High Very High Very High
Low Back Pain 6 98.50 Very High Very High Very High
Fatigue 24 96.36 Very High Very High Very High
Poisoning 3 86.56 High High
Hypothermia 1 83.32 Quite High
Disease 2 72.72 Quite High
Stress 9 34.20 Quite Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Respiratory Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A minor effect on TYR release in the presence of GLY-GLY-PHE-MET (50 microM) was insignificant.
Localization (release) of TYR
1) Confidence 0.68 Published 1987 Journal Life Sci. Section Abstract Doc Link 2955188 Disease Relevance 0.24 Pain Relevance 0.63
An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments.
Localization (release) of Tyr in brain
2) Confidence 0.49 Published 1984 Journal J. Neurosci. Res. Section Abstract Doc Link 6737520 Disease Relevance 0 Pain Relevance 0
The enkephalins are degraded in vitro by three types of metallopeptidases including a dipeptidylaminopeptidase (DAP) which releases Tyr-Gly.
Localization (releases) of Tyr associated with enkephalin
3) Confidence 0.14 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.35
These bands are weaker for IV, which maybe due to the presence of a second Tyr residue in that peptide, giving an opposite contribution to the CD spectrum as that arising from Tyr1.
Localization (presence) of Tyr in bands
4) Confidence 0.12 Published 2006 Journal J. Pept. Sci. Section Abstract Doc Link 16180245 Disease Relevance 0 Pain Relevance 0.14
Nybo et al. [8] however, found that brain uptake of Trp and Tyr as well as brain DA release were not affected by hyperthermia, failing therefore to support the classic "5-HT-central fatigue hypothesis" [37]; and also the involvement of brain DA function in thermoregulation during exercise in the heat.
Localization (release) of Tyr in brain associated with dopamine, fatigue and fever
5) Confidence 0.11 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.60 Pain Relevance 0.48
Quantitative autoradiographic localization of [125I-Tyr8]bradykinin receptor binding sites in the rat spinal cord: effects of neonatal capsaicin, noradrenergic deafferentation, dorsal rhizotomy and peripheral axotomy.
Localization (localization) of Tyr8 in spinal cord associated with dorsal rhizotomy, qutenza, bradykinin, deafferentation and spinal cord
6) Confidence 0.03 Published 1995 Journal Neuroscience Section Title Doc Link 8577380 Disease Relevance 0 Pain Relevance 0.69
A common feature shared by the two caucasoid AS-associated subtypes (B*2702 and B*2705) but different from B*2709, is the presence of a Tyr as peptide C-terminal anchor.
Localization (presence) of Tyr associated with spinal inflammation
7) Confidence 0.03 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9045906 Disease Relevance 0.47 Pain Relevance 0.48
From amongst the various peptide fragments produced, Tyr-Gly-Gly was subject to immediate aminopeptidase action to release Tyr and Gly-Gly.
Localization (release) of Tyr
8) Confidence 0.01 Published 1997 Journal Toxicon Section Abstract Doc Link 9248009 Disease Relevance 0 Pain Relevance 0.44
By one route, an endopeptidase cleaved the Gly-Phe bond of enkephalin first to release Tyr-Gly-Gly and Phe-Met.
Localization (release) of Tyr associated with enkephalin
9) Confidence 0.01 Published 1997 Journal Toxicon Section Abstract Doc Link 9248009 Disease Relevance 0 Pain Relevance 0.42
By the other route, an aminopeptidase was able to release Tyr and Gly-Gly-Phe-Met by cleaving the Tyr-Gly bond first.
Localization (release) of Tyr
10) Confidence 0.01 Published 1997 Journal Toxicon Section Abstract Doc Link 9248009 Disease Relevance 0 Pain Relevance 0.43
After derivatization with PITC of the N-terminal amino acid (L-Tyr) of an enkephalin analogue, [D-Ala2, D-Leu5]-enkephalin, followed by cleavage/cyclization with trifluoroacetic acid at 50 degrees C for 5 min, the liberated 2-anilino-5-thiazolinone-L-Tyr (ATZ-L-Tyr) was further treated with 20% aqueous trifluoroacetic acid at 50 degrees C for 10 min.
Localization (liberated) of L-Tyr in cleavage associated with enkephalin
11) Confidence 0.01 Published 1995 Journal Biomed. Chromatogr. Section Abstract Doc Link 8520211 Disease Relevance 0 Pain Relevance 0.20

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