INT32452

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.60
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 5
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
antiallodynic 6 98.40 Very High Very High Very High
aspirin 7 93.60 High High
Angina 2 89.36 High High
antagonist 12 85.60 High High
cerebral cortex 2 68.80 Quite High
Inflammation 21 50.00 Quite Low
Analgesic 6 50.00 Quite Low
Inflammatory mediators 3 45.60 Quite Low
allodynia 4 43.64 Quite Low
Disease Link Frequency Relevance Heat
Septic Shock 22 99.48 Very High Very High Very High
INFLAMMATION 29 99.10 Very High Very High Very High
Thrombosis 6 98.38 Very High Very High Very High
Increased Venous Pressure Under Development 1 93.92 High High
Stroke 2 91.60 High High
Cv General 4 Under Development 1 90.24 High High
Cv General 3 Under Development 2 89.36 High High
Brain Hemorrhage 1 88.56 High High
Pressure And Volume Under Development 2 80.32 Quite High
Cardiovascular Disease 4 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ticlopidine and clopidogrel achieve antiplatelet effects by inhibiting the binding of adenosine 5'-disphosphate to its platelet receptor.
platelet receptor Binding (binding) of in platelet associated with adenocard
1) Confidence 0.42 Published 1998 Journal Ann. Intern. Med. Section Abstract Doc Link 9735068 Disease Relevance 0.45 Pain Relevance 0.16
Evidence for interaction with platelet activating factor receptor.
platelet activating factor Binding (interaction) of in platelet
2) Confidence 0.31 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16925995 Disease Relevance 0.41 Pain Relevance 0.12
Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock.
Platelet-activating factor Binding (associated) of in Platelet associated with septic shock
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2714981 Disease Relevance 0.62 Pain Relevance 0
In the present study, we have assessed whether the antiinflammatory actions of these lignans can be mediated by interaction with platelet activating factor (PAF) receptor or interference with the action of this lipid.
platelet activating factor Binding (interaction) of in platelet associated with inflammation
4) Confidence 0.23 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16925995 Disease Relevance 0.35 Pain Relevance 0.11
Acute arterial thrombosis may require more potent, immediate and transient intervention, e.g., monoclonal antibody to platelet receptor expression.
platelet receptor Binding (antibody) of in platelet associated with thrombosis
5) Confidence 0.00 Published 1987 Journal Am. J. Cardiol. Section Abstract Doc Link 2956836 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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