INT324526

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.31 Pain Relevance 0.03

Anatomy Link Frequency lens capsules 2 kidney 2 AREG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 95 61.32 agonist 52 35.00 Arthritis 10 5.00 Inflammatory mediators 8 5.00 antagonist 8 5.00 cytokine 7 5.00 Inflammatory response 6 5.00 COX2 3 5.00 cINOD 3 5.00 diclofenac 2 5.00

Disease Link Frequency Relevance Heat Hyperplasia 5 98.88 Chronic Obstructive Pulmonary Disease 4 98.24 Colitis 67 96.00 Cancer 85 86.80 Cleidocranial Dysplasia 12 85.88 Metastasis 8 85.36 Cataract 19 80.40 Carcinoma 2 72.28 INFLAMMATION 109 61.32 Capsule Opacification 45 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].

Positive_regulation (increased) of Gene_expression (expression) of amphiregulin associated with chronic obstructive pulmonary disease

1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.55 Pain Relevance 0

Our array data has demonstrated that amphiregulin expression is also substantially induced in kidney cells by PAR2 activation and this may be important in proliferation of kidney cells.

Positive_regulation (induced) of Gene_expression (expression) of amphiregulin in kidney

2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.51 Pain Relevance 0

AR-12 treated ex vivo lens capsules

Positive_regulation (treated) of Gene_expression (treated) of AR-12 in lens capsules

3) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.24 Pain Relevance 0

Lastly, PGE 2 treatment increased mucosal expression of AR and Cox-2, thus inducing EGFR activation and forming a positive feedback mechanism to amplify mucosal Cox-2.

Positive_regulation (increased) of Gene_expression (expression) of AR

4) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912804 Disease Relevance 1.01 Pain Relevance 0.03

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