INT324526

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.31
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lens capsules 2
kidney 2
AREG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 95 61.32 Quite High
agonist 52 35.00 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 5 98.88 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 4 98.24 Very High Very High Very High
Colitis 67 96.00 Very High Very High Very High
Cancer 85 86.80 High High
Cleidocranial Dysplasia 12 85.88 High High
Metastasis 8 85.36 High High
Cataract 19 80.40 Quite High
Carcinoma 2 72.28 Quite High
INFLAMMATION 109 61.32 Quite High
Capsule Opacification 45 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].
Positive_regulation (increased) of Gene_expression (expression) of amphiregulin associated with chronic obstructive pulmonary disease
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.55 Pain Relevance 0
Our array data has demonstrated that amphiregulin expression is also substantially induced in kidney cells by PAR2 activation and this may be important in proliferation of kidney cells.


Positive_regulation (induced) of Gene_expression (expression) of amphiregulin in kidney
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.51 Pain Relevance 0
AR-12 treated ex vivo lens capsules
Positive_regulation (treated) of Gene_expression (treated) of AR-12 in lens capsules
3) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.24 Pain Relevance 0
Lastly, PGE 2 treatment increased mucosal expression of AR and Cox-2, thus inducing EGFR activation and forming a positive feedback mechanism to amplify mucosal Cox-2.


Positive_regulation (increased) of Gene_expression (expression) of AR
4) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912804 Disease Relevance 1.01 Pain Relevance 0.03

General Comments

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