INT32453

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 7.01
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
nerve 6
platelet 4
macrophages 1
neurons 1
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 376 100.00 Very High Very High Very High
cytokine 80 100.00 Very High Very High Very High
Inflammation 47 100.00 Very High Very High Very High
Brush evoked pain 192 94.16 High High
Peripheral nerve injury 52 93.44 High High
aspirin 15 92.76 High High
Angina 1 92.40 High High
antagonist 37 91.16 High High
Inflammatory response 2 89.84 High High
Spinal cord 28 88.96 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 380 100.00 Very High Very High Very High
INFLAMMATION 46 100.00 Very High Very High Very High
Thrombosis 5 99.90 Very High Very High Very High
Nervous System Injury 232 99.72 Very High Very High Very High
Inflammatory Bowel Disease 54 99.52 Very High Very High Very High
Injury 18 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.96 Very High Very High Very High
Neuropathic Pain 264 94.16 High High
Cv General 3 Under Development 1 92.40 High High
Brain Hemorrhage 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data from real-time RT-PCR analyses showed that PAFR gene expression was increased in the ipsilateral DRG after nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.72 Pain Relevance 1.18
PAF may be released from DRG neurons and then activates PAFR expressed in macrophages.
Positive_regulation (activates) of in neurons Gene_expression (expressed) of PAFR in macrophages associated with dorsal root ganglion
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.08 Pain Relevance 0.74
We found that the expression of PAFR mRNA in the ipsilateral DRG was markedly increased after nerve injury (Fig. 6A).
Positive_regulation (increased) of Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.37 Pain Relevance 0.55
These results indicate that PAFR expression in the DRG is upregulated in macrophages after nerve injury.


Positive_regulation (upregulated) of Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.84 Pain Relevance 0.34
As in other inflammatory processes, IBD is characterized by an upregulation in the synthesis and release of different pro-inflammatory cytokines, including reactive oxygen and nitrogen metabolites, eicosanoids, platelet-activating factor, and cytokines (Stenson 1994).
Positive_regulation (upregulation) of Gene_expression (synthesis) of platelet-activating factor in platelet associated with inflammatory bowel disease, inflammation and cytokine
5) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721377 Disease Relevance 1.14 Pain Relevance 0.48
Acute arterial thrombosis may require more potent, immediate and transient intervention, e.g., monoclonal antibody to platelet receptor expression.
Spec (may) Positive_regulation (require) of Gene_expression (expression) of platelet receptor in platelet associated with thrombosis
6) Confidence 0.00 Published 1987 Journal Am. J. Cardiol. Section Abstract Doc Link 2956836 Disease Relevance 0.80 Pain Relevance 0.18

General Comments

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