INT32454

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Context Info
Confidence 0.65
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 15.19
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
macrophages 4
nerve 3
platelet 2
spleen 1
microglia 1
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 233 100.00 Very High Very High Very High
Inflammation 65 100.00 Very High Very High Very High
dorsal root ganglion 1222 99.68 Very High Very High Very High
Peripheral nerve injury 169 98.12 Very High Very High Very High
Brush evoked pain 624 97.94 Very High Very High Very High
withdrawal 195 92.08 High High
antagonist 118 91.16 High High
Inflammatory response 2 89.84 High High
aspirin 15 89.24 High High
Spinal cord 91 88.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 64 100.00 Very High Very High Very High
Ganglion Cysts 1235 99.68 Very High Very High Very High
Nervous System Injury 754 99.28 Very High Very High Very High
Inflammatory Bowel Disease 54 99.12 Very High Very High Very High
Injury 54 98.28 Very High Very High Very High
Thrombosis 5 98.14 Very High Very High Very High
Neuropathic Pain 858 97.94 Very High Very High Very High
Increased Venous Pressure Under Development 1 93.44 High High
Necrosis 28 90.00 High High
Cv General 3 Under Development 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAF may be released from DRG neurons and then activates PAFR expressed in macrophages.
Gene_expression (expressed) of PAFR in macrophages associated with dorsal root ganglion
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.07 Pain Relevance 0.74
Alternatively, infiltration of macrophages expressing PAFR in the DRG after nerve injury might result in the upregulation of PAFR mRNA, because PAFR is expressed in macrophages [35] and is involved in macrophage chemotaxis [48] and the number of macrophages in the DRG is increased following peripheral nerve injury [49].
Gene_expression (expressing) of PAFR in macrophage associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.53 Pain Relevance 0.90
Our data from real-time RT-PCR analyses showed that PAFR gene expression was increased in the ipsilateral DRG after nerve injury.
Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.71 Pain Relevance 1.18
Alternatively, infiltration of macrophages expressing PAFR in the DRG after nerve injury might result in the upregulation of PAFR mRNA, because PAFR is expressed in macrophages [35] and is involved in macrophage chemotaxis [48] and the number of macrophages in the DRG is increased following peripheral nerve injury [49].
Gene_expression (expressed) of PAFR in macrophage associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.45 Pain Relevance 0.86
Because a mechanism underlying LPAR-mediated tactile allodynia has been previously demonstrated [12], [31], in the present study we investigated the role of the PAF-PAFR system in the DRG.
Gene_expression (system) of PAFR associated with dorsal root ganglion and brush evoked pain
5) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.48 Pain Relevance 0.97
We found that the expression of PAFR mRNA in the ipsilateral DRG was markedly increased after nerve injury (Fig. 6A).
Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.35 Pain Relevance 0.54
To identify the type of cells expressing PAFR, we performed in situ hybridization combined with immunohistochemistry for the macrophages/microglia marker Iba1 (ionized calcium-binding adapter molecule-1) and the satellite cells marker GFAP (glial fibrillary acidic protein).
Gene_expression (expressing) of PAFR in microglia
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.75 Pain Relevance 0.31
We validated the hybridization efficiency of antisense and sense probes used in this study with the spleen sections where the PAFR expression is known to be high [35] (Fig.
Gene_expression (expression) of PAFR in spleen
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.69 Pain Relevance 0.25
These results indicate that PAFR expression in the DRG is upregulated in macrophages after nerve injury.


Gene_expression (expression) of PAFR in nerve associated with dorsal root ganglion and nervous system injury
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.83 Pain Relevance 0.34
The TaqMan probe, forward primer and reverse primer used in this study were designed as follows: rat PAFR, probe, 5?
Gene_expression (probe) of PAFR
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.18 Pain Relevance 0.09
The TaqMan probe, forward primer and reverse primer used in this study were designed as follows: rat PAFR, probe, 5?
Gene_expression (follows) of PAFR
11) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.18 Pain Relevance 0.09
expression in pafr?
Gene_expression (expression) of pafr
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.22 Pain Relevance 0.63
To identify the type of cells expressing PAFR, we performed in situ hybridization combined with immunohistochemistry for the macrophages/microglia marker Iba1 (ionized calcium-binding adapter molecule-1) and the satellite cells marker GFAP (glial fibrillary acidic protein).
Gene_expression (expressing) of PAFR in macrophages
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.75 Pain Relevance 0.31
As in other inflammatory processes, IBD is characterized by an upregulation in the synthesis and release of different pro-inflammatory cytokines, including reactive oxygen and nitrogen metabolites, eicosanoids, platelet-activating factor, and cytokines (Stenson 1994).
Gene_expression (synthesis) of platelet-activating factor in platelet associated with inflammatory bowel disease, inflammation and cytokine
14) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721377 Disease Relevance 1.14 Pain Relevance 0.48
Acute arterial thrombosis may require more potent, immediate and transient intervention, e.g., monoclonal antibody to platelet receptor expression.
Gene_expression (expression) of platelet receptor in platelet associated with thrombosis
15) Confidence 0.01 Published 1987 Journal Am. J. Cardiol. Section Abstract Doc Link 2956836 Disease Relevance 0.77 Pain Relevance 0.18

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