INT32458

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 57
Total Number 60
Disease Relevance 28.97
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
plasma 9
Endothelial cells 6
blood 4
platelet 3
brain 2
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 67 99.68 Very High Very High Very High
Inflammation 388 99.16 Very High Very High Very High
cytokine 103 98.20 Very High Very High Very High
ischemia 62 97.28 Very High Very High Very High
cva 22 96.98 Very High Very High Very High
agonist 15 96.60 Very High Very High Very High
anesthesia 24 93.16 High High
fibrosis 8 92.64 High High
abdominal pain 8 89.80 High High
Inflammatory marker 14 85.28 High High
Disease Link Frequency Relevance Heat
Adhesions 163 99.88 Very High Very High Very High
Cv General 3 Under Development 71 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 218 99.64 Very High Very High Very High
Cv Unclassified Under Development 63 99.64 Very High Very High Very High
INFLAMMATION 465 99.52 Very High Very High Very High
Thrombosis 45 99.52 Very High Very High Very High
Coronary Artery Disease 143 99.40 Very High Very High Very High
Myocardial Infarction 89 98.94 Very High Very High Very High
Congenital Anomalies 34 98.52 Very High Very High Very High
Diabetes Mellitus 882 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial cells are able to synthesize von Willebrand factor (vWf) protein, which is then either secreted in a constitutive way or stored within specific cellular secretory granules, the Weibel-Palade bodies.
Gene_expression (synthesize) of vWf in Endothelial cells
1) Confidence 0.78 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.12
This cell line, which co-expresses full-length FVIII and von Willebrand Factor (VWF), did not undergo any genetic manipulations, and the cDNA coding sequence of the recombinant proteins remained identical to those used for Recombinate¬ģ.
Gene_expression (expresses) of VWF
2) Confidence 0.75 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291300 Disease Relevance 0.08 Pain Relevance 0
Endothelial cells were identified by their expression of an endothelial cell marker, Factor VIII/von Willebrand factor.
Gene_expression (expression) of von Willebrand factor in Endothelial cells
3) Confidence 0.75 Published 1994 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 7820365 Disease Relevance 0.35 Pain Relevance 0.18
Median levels of fibrinogen, von Willebrand factor (VWF), tissue plasminogen activator (t-PA) antigen, fibrin D-dimer and whole blood viscosity were significantly higher in those who experienced an event compared with those who did not.
Gene_expression (levels) of von Willebrand factor in blood
4) Confidence 0.75 Published 1998 Journal Br. J. Haematol. Section Abstract Doc Link 9531345 Disease Relevance 1.14 Pain Relevance 0.08
The factor VIII-von Willebrand factor complex was documented in 84 patients, and plasma von Willebrand factor level was decreased (<60%) in 23 (27%) of them; 10 of the 84 patients (12%) had more notably decreased levels (<50%).
Gene_expression (documented) of von Willebrand factor in plasma
5) Confidence 0.66 Published 2008 Journal Arch Dermatol Section Body Doc Link 18645137 Disease Relevance 0 Pain Relevance 0
Along with ROS, VEGF, and a large number of mature and immature CD31/vWF positive blood vessels were present in the adhesion tissue.
Gene_expression (present) of vWF in blood vessels associated with adhesions
6) Confidence 0.65 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.30 Pain Relevance 0
Furthermore, in a canine thromboembolic brain ischemia model, transplanted CB-MSCs had differentiated into neurons and astrocytes and were observed in and around endothelial cells that were positive for von Willebrand factor (vWF) [60].
Gene_expression (positive) of von Willebrand factor in brain associated with brain hemorrhage, ischemia and cva
7) Confidence 0.65 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.42 Pain Relevance 0.16
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Gene_expression (levels) of vWF associated with diabetes mellitus
8) Confidence 0.64 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.20 Pain Relevance 0.04
The plasma levels of vWF, PAI-1, tPA, f-TFPI, and s-TM were measured using commercially available enzyme-linked immunosorbent assays (Diagnostica Stago, Asnières, France).


Gene_expression (levels) of vWF in plasma
9) Confidence 0.64 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.42 Pain Relevance 0.09
Nevertheless, correlation between CTFC and IL-6, hsCRP, vWF levels was not found.
Gene_expression (levels) of vWF
10) Confidence 0.62 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16297392 Disease Relevance 1.31 Pain Relevance 0.18
The relation was independent from age, gender, BMI, smoking, hypertension, diabetes, previous myocardial infarction, family history of IHD, medication, hsCRP, IL-6 and vWF levels.
Gene_expression (levels) of vWF associated with coronary artery disease, nicotine addiction, diabetes mellitus, hypertension and myocardial infarction
11) Confidence 0.62 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16297392 Disease Relevance 1.45 Pain Relevance 0.19
Endothelial cells are able to synthesize von Willebrand factor (vWf) protein, which is then either secreted in a constitutive way or stored within specific cellular secretory granules, the Weibel-Palade bodies.
Gene_expression (synthesize) of von Willebrand factor in Endothelial cells
12) Confidence 0.60 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.12
CONCLUSIONS: In patients with angina pectoris, the levels of fibrinogen, von Willebrand factor antigen, and t-PA antigen are independent predictors of subsequent acute coronary syndromes.
Gene_expression (levels) of von Willebrand factor
13) Confidence 0.58 Published 1995 Journal N. Engl. J. Med. Section Body Doc Link 7845427 Disease Relevance 0 Pain Relevance 0
METHODS: Plasma levels of von Willebrand factor (vWF) antigen, vWF collagen binding activity, vWF-cleaving-protease, CRP, and whole-blood platelet reactivity were measured before and 24 h after angioplasty in 18 patients with recent unstable angina and in 17 with stable angina.
Gene_expression (levels) of von Willebrand factor in blood platelet
14) Confidence 0.58 Published 2002 Journal J. Thromb. Thrombolysis Section Body Doc Link 12714832 Disease Relevance 0.19 Pain Relevance 0
The European Concerted Action on Thrombosis (ECAT) showed that the levels of fibrinogen, von Willebrand factor antigen, and t-PA antigen are independent predictors of subsequent coronary syndromes in patients with angina pectoris, and that low fibrinogen is associated with a low risk of events despite high cholesterol levels.
Gene_expression (levels) of von Willebrand factor associated with angina, syndrome and thrombosis
15) Confidence 0.58 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9519344 Disease Relevance 1.56 Pain Relevance 0.10
To maintain vascular homeostasis, the endothelium produces components of the extracellular matrix such as collagen and a variety of regulatory chemical mediators, including nitric oxide (NO), prostanoids (prostacycline), endothelin-1 (ET-1), angiotensin II (ANG-II), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF), adhesion molecules (VCAM, LAM, ICAM), and cytokines, among them Tumor Necrosis Factor ?
Gene_expression (produces) of von Willebrand factor in extracellular matrix associated with necrosis, cancer, adhesions and cytokine
16) Confidence 0.58 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.29 Pain Relevance 0.13
We then observed that VEGF stimulated HSCs to differentiate into endothelial-like cells, which expressed von Willebrand factor and formed intercellular tubular structures in vitro.
Gene_expression (expressed) of von Willebrand factor
17) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
As a final and practical note, the apparent progression seen in our data from normal plasma levels of vWF, f-TFPI and s-TM as well as a normal PWV in diabetics without vascular or renal complications, to generalized abnormalities of these parameters when such complications are detected, suggests that the serial measurement of some, or possibly all, of these parameters might be useful for the long term monitoring of these patients.
Gene_expression (levels) of vWF in plasma associated with congenital anomalies and diabetes mellitus
18) Confidence 0.50 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.64 Pain Relevance 0
A 10-mL blood sample was first collected in a prechilled sodium citrate-coated tube for determining circulating levels of PAI-1, vWF, tPA, f-TFPI, and s-TM.
Gene_expression (levels) of vWF in tube
19) Confidence 0.50 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.43 Pain Relevance 0.04
Measurement of plasma concentrations of protein C and von Willebrand Factor (vWF)
Gene_expression (concentrations) of von Willebrand Factor in plasma
20) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.06 Pain Relevance 0

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