INT324607

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 10.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SNCG) microtubule organizing center (SNCG) cytoplasm (SNCG)
Anatomy Link Frequency
colon 2
SNCG (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 96 99.90 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 8 99.90 Very High Very High Very High
Colon Cancer 416 99.88 Very High Very High Very High
Disease 64 99.60 Very High Very High Very High
Recurrence 208 99.44 Very High Very High Very High
Adenocarcinoma 32 99.24 Very High Very High Very High
Hyperplasia 24 99.20 Very High Very High Very High
Cancer 408 99.00 Very High Very High Very High
Neurodegenerative Disease 16 97.76 Very High Very High Very High
Metastasis 104 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNCG overexpression correlates with poor outcome and is an independent prognostic indicator
Positive_regulation (overexpression) of Gene_expression (overexpression) of SNCG
1) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 2.19 Pain Relevance 0
SNCG was overexpressed in 35% (34/97) of adenocarcinoma tissues from patients with normal preoperative serum CEA level.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SNCG associated with adenocarcinoma
2) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.67 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Positive_regulation (positive) of Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
3) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.72 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Positive_regulation (positive) of Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
4) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.87 Pain Relevance 0
There were 42% (45/108) of patients with elevated CEA levels in the SNCG negative group, rates of DFS and OS of these patients were 43% and 39% at 5 year after surgery.
Positive_regulation (elevated) of Neg (negative) Gene_expression (group) of SNCG
5) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.68 Pain Relevance 0
SNCG is overexpressed in colon adenocarcinoma cells and is associated with intravascular embolus
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SNCG in colon associated with embolism and colon cancer
6) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.97 Pain Relevance 0
SNCG overexpression correlates with poor outcome and remains an independent prognostic indicator for patients with normal preoperative serum CEA level
Positive_regulation (overexpression) of Gene_expression (overexpression) of SNCG
7) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.59 Pain Relevance 0
SNCG overexpression in breast cancer cells stimulates proliferation, induces metastasis, promotes chromosomal instability, inhibits mitotic checkpoint [12,17-19], and increases resistance to certain chemotherapeutic or anti-microtubule agents [20,21], however down-regulation of SNCG expression sensitizes breast cancer cells to anti-microtubule agents-induced cytotoxicity [20-22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SNCG associated with chromosomal instability, breast cancer and metastasis
8) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.65 Pain Relevance 0

General Comments

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