INT324609

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 5.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SNCG) microtubule organizing center (SNCG) cytoplasm (SNCG)
SNCG (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 36 99.90 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 99.90 Very High Very High Very High
Hyperplasia 9 99.20 Very High Very High Very High
Chromosomal Instability 3 97.12 Very High Very High Very High
Metastasis 39 96.44 Very High Very High Very High
Disease 24 89.00 High High
Neurodegenerative Disease 6 87.16 High High
Cancer 153 86.80 High High
Malignant Neoplastic Disease 12 86.24 High High
Colon Cancer 156 69.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNCG overexpression in breast cancer cells stimulates proliferation, induces metastasis, promotes chromosomal instability, inhibits mitotic checkpoint [12,17-19], and increases resistance to certain chemotherapeutic or anti-microtubule agents [20,21], however down-regulation of SNCG expression sensitizes breast cancer cells to anti-microtubule agents-induced cytotoxicity [20-22].
Negative_regulation (regulation) of Gene_expression (expression) of SNCG associated with chromosomal instability, breast cancer and metastasis
1) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.61 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Negative_regulation (positive) of Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
2) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.72 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Negative_regulation (positive) of Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
3) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.87 Pain Relevance 0

General Comments

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