INT32464

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.46
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
MEFs 2
chondrocytes 1
joint 1
articular 1
cartilage 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 109 100.00 Very High Very High Very High
Arthritis 141 99.28 Very High Very High Very High
rheumatoid arthritis 144 98.28 Very High Very High Very High
Inflammation 153 97.56 Very High Very High Very High
diclofenac 4 94.48 High High
fibrosis 46 93.04 High High
ischemia 22 92.16 High High
Inflammatory response 21 87.80 High High
cytokine 50 85.16 High High
cINOD 9 84.48 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 200 99.84 Very High Very High Very High
Arthritis 156 99.68 Very High Very High Very High
Severe Combined Immunodeficiency 56 99.06 Very High Very High Very High
Arthropathy 4 98.40 Very High Very High Very High
INFLAMMATION 190 97.56 Very High Very High Very High
Chronic Lymphoid Leukemia 1 97.00 Very High Very High Very High
Disease 65 93.52 High High
Fibrosis 28 93.04 High High
Death 29 92.68 High High
Cv General 4 Under Development 5 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies, however, have shown that multiple tetracyclines can inhibit collagenase MMPs via down-regulation of gene expression in a cellular model of rheumatoid arthritis using cultured chondrocytes [33] and that pre-treatment with minocycline down-regulates pro-MMP expression after permanent cerebral ischemia [17].
Regulation (regulation) of collagenase in chondrocytes associated with cv general 4 under development, ischemia and rheumatoid arthritis
1) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.53 Pain Relevance 0.20
Localization of GFP to filaments is sensitive to collagenase
Regulation (sensitive) of collagenase in filaments
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2761730 Disease Relevance 0 Pain Relevance 0
Since in the non-inflammatory SCID mouse model, MMP-1 is only expressed constitutively by the implanted human cells, this might account for the higher efficiency of the MMP-13 inhibitor in this model.
Spec (might) Regulation (efficiency) of MMP-13 associated with inflammation and severe combined immunodeficiency
3) Confidence 0.43 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.44 Pain Relevance 0.23
McolB is apparently devoid of collagenolytic activity.18 Thus, we cannot exclude the possibility that the missing effect of the MMP-13 inhibitor in the AIA model is due to the induction of MMP-1 in a highly inflammatory milieu.
Regulation (effect) of MMP-13 associated with inflammation and arthritis
4) Confidence 0.43 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.50 Pain Relevance 0.21
In addition, the effect of the drugs on the aggressive action of collagenase on the articular surface was tested using the same in vitro system.
Regulation (effect) of collagenase in articular
5) Confidence 0.42 Published 1987 Journal Clin. Rheumatol. Section Abstract Doc Link 2957142 Disease Relevance 0.08 Pain Relevance 0.17
It has been shown that inhibition of MMP-1 by ribozymes has a protective effect on cartilage erosion in the SCID mouse co-implantation model.14 Both MMP-1 and MMP-13 contribute to the process of cartilage destruction in RA and can therefore be targeted for treatment.
Regulation (contribute) of MMP-13 in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
6) Confidence 0.37 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.19 Pain Relevance 0.41
However, it could be that the MMPs or collagenases, in spite of their presence within the joint, are the wrong target in the arthritides, and that other enzyme systems such as cathepsin K predominate [126,127].
Regulation (target) of collagenase in joint associated with metalloproteinase and arthritis
7) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.65 Pain Relevance 0.31
The drugs studied had no effect on the disruptive action of collagenase.
Neg (no) Regulation (effect) of collagenase
8) Confidence 0.25 Published 1987 Journal Clin. Rheumatol. Section Abstract Doc Link 2957142 Disease Relevance 0.07 Pain Relevance 0.15
Physiologically MMP-13 activity is controlled by naturally occurring inhibitors such as ?
Regulation (controlled) of MMP-13
9) Confidence 0.22 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.35 Pain Relevance 0.28
To examine whether CpdA exerts its repressive activity via the GR, we studied regulation of matrix metalloproteinase 13 (MMP-13) in mouse embryonic fibroblasts (MEFs).
Regulation (regulation) of matrix metalloproteinase 13 in MEFs associated with metalloproteinase
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.48 Pain Relevance 0.39
To examine whether CpdA exerts its repressive activity via the GR, we studied regulation of matrix metalloproteinase 13 (MMP-13) in mouse embryonic fibroblasts (MEFs).
Regulation (regulation) of MMP-13 in MEFs associated with metalloproteinase
11) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.48 Pain Relevance 0.39
The decreased collagen levels in mice lacking a collagenase suggested that the benefits seen in these animals were not related to the effects of MMP-8 on the extracellular matrix proteins.
Regulation (lacking) of collagenase in extracellular matrix
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.62 Pain Relevance 0.32
including MMP-1 and MMP-13 appeared to be influenced by RA as well [59].


Regulation (influenced) of MMP-13 associated with rheumatoid arthritis and metalloproteinase
13) Confidence 0.03 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.05 Pain Relevance 0.55

General Comments

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