INT324692

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14)
Anatomy Link Frequency
microglia 1
Cd14 (Mus musculus)
Sod1m (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1 57.28 Quite High
Inflammatory response 7 8.68 Low Low
Central nervous system 21 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 98.36 Very High Very High Very High
Drug Induced Neurotoxicity 6 98.28 Very High Very High Very High
Disease 55 93.72 High High
Targeted Disruption 9 91.00 High High
Motor Neuron Diseases 11 83.96 Quite High
Disease Progression 5 73.68 Quite High
Death 9 62.00 Quite High
Nerve Degeneration 2 44.40 Quite Low
Neurodegenerative Disease 17 32.44 Quite Low
Prion Diseases 13 27.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zhao et al. [116] have demonstrated that mSOD1 binds to CD14, which has a role in the activation and toxicity of microglia treated with extracellular mSOD1.
CD14 Binding (binds) of mSOD1 in microglia associated with toxicity
1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.07 Pain Relevance 0.03

General Comments

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