INT324694

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) extracellular region (Pnoc) plasma membrane (Tlr4)
intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
neurons 2
Tlr4 (Mus musculus)
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 1 100.00 Very High Very High Very High
Opioid 1 99.80 Very High Very High Very High
Neuropeptide 1 99.20 Very High Very High Very High
agonist 15 78.16 Quite High
Central nervous system 21 40.88 Quite Low
Demyelination 1 30.08 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 86.76 High High
Death 9 84.04 Quite High
Shock 2 82.44 Quite High
Drug Induced Neurotoxicity 6 55.60 Quite High
Cold Sores 1 53.16 Quite High
Rabies Virus Infection 1 51.80 Quite High
Disease 55 50.00 Quite Low
Viral Infection 2 49.32 Quite Low
Demyelinating Disease 1 30.08 Quite Low
Injury 3 25.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Engagement of TLR4 on neurons induces the expression of nociceptin, an opioid-related neuropeptide [58].
TLR4 Positive_regulation (induces) of Gene_expression (expression) of nociceptin in neurons associated with orphanin, neuropeptide and opioid
1) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.56 Pain Relevance 0.24

General Comments

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