INT32474

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Context Info
Confidence 0.12
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.64
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF3K) nucleolus (EIF3K) nucleus (EIF3K)
translation (EIF3K) cytoplasm (EIF3K)
Anatomy Link Frequency
muscle 7
skeletal muscle 2
EIF3K (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 12 99.82 Very High Very High Very High
sodium channel 5 99.38 Very High Very High Very High
tolerance 26 82.00 Quite High
imagery 2 64.96 Quite High
Inflammatory marker 4 50.00 Quite Low
agonist 2 48.32 Quite Low
antagonist 2 47.36 Quite Low
cytokine 2 46.08 Quite Low
addiction 1 25.00 Low Low
Action potential 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Paralysis 4 99.92 Very High Very High Very High
Diabetes Mellitus 165 99.02 Very High Very High Very High
Impaired Glucose Tolerance 26 82.00 Quite High
Thyroid Disease 2 79.68 Quite High
Liver Disease 1 79.04 Quite High
Disease 39 77.84 Quite High
Apoptosis 8 54.80 Quite High
Insulin Resistance 70 50.00 Quite Low
INFLAMMATION 10 50.00 Quite Low
Congenital Anomalies 1 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An immortal, cloned cell line (RCMH), obtained from human skeletal muscle was established in our laboratory and shown to express muscle specific proteins.
Gene_expression (express) of muscle specific in skeletal muscle
1) Confidence 0.12 Published 1997 Journal J. Muscle Res. Cell. Motil. Section Abstract Doc Link 9350011 Disease Relevance 0 Pain Relevance 0.03
Since we observed an inverse relationship between 'muscle development' miRNAs and changes in diabetes, we further investigated the reason for altered expression of the muscle specific miRNAs.


Gene_expression (expression) of muscle specific in muscle associated with diabetes mellitus
2) Confidence 0.10 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.95 Pain Relevance 0.07
Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle.
Gene_expression (expression) of muscle-specific in muscle
3) Confidence 0.07 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
We studied the effect of electrical stimulation and a sodium channel blocker (tetrodotoxin) on the expression of muscle-specific isozymes of creatine kinase, glycogen phosphorylase, phosphoglycerate mutase, and lactate dehydrogenase in aneurally cultured embryonic rat muscle.
Gene_expression (expression) of muscle-specific in muscle associated with tetrodotoxin and sodium channel
4) Confidence 0.06 Published 1987 Journal Exp. Neurol. Section Abstract Doc Link 2957228 Disease Relevance 0.07 Pain Relevance 0.22
Muscle contractile activity slightly accelerated the accumulation of muscle-specific isozyme of creatine kinase in early cultures (4 days of experiment), but no increase in the expression of muscle-specific isozymes of any enzyme was present in older cultures (11 days of experiment).
Gene_expression (expression) of muscle-specific in muscle
5) Confidence 0.06 Published 1987 Journal Exp. Neurol. Section Abstract Doc Link 2957228 Disease Relevance 0.07 Pain Relevance 0.20
Effects of electrical stimulation and tetrodotoxin paralysis on expression of muscle-specific isozymes of four enzymes in aneurally cultured embryonic rat muscle.
Gene_expression (expression) of muscle-specific in muscle associated with tetrodotoxin and paralysis
6) Confidence 0.06 Published 1987 Journal Exp. Neurol. Section Title Doc Link 2957228 Disease Relevance 0.10 Pain Relevance 0.24
Little is known about the expression of skeletal muscle-specific isoforms of IGF-I gene in response to exercise in humans, nor the influence of age and physical training status.
Gene_expression (expression) of muscle-specific in skeletal muscle
7) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.37 Pain Relevance 0.03
Nuclei in multinucleated skeletal muscle fibers are capable of expressing different sets of muscle-specific genes depending on their locations within the fiber.
Gene_expression (expressing) of muscle-specific in muscle
8) Confidence 0.01 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648696 Disease Relevance 0 Pain Relevance 0.14
The muscle-specific helix-loop-helix (HLH) transcription factors myoD, myogenin, MRF4, and myf-5 are called the muscle regulatory factor family (MRF).
Gene_expression (called) of muscle-specific in muscle
9) Confidence 0.01 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10951440 Disease Relevance 0.06 Pain Relevance 0.06

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