INT324756

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.87
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Anatomy Link Frequency
A20 1
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 61 81.88 Quite High
Inflammation 225 81.20 Quite High
tolerance 42 64.16 Quite High
agonist 10 22.32 Low Low
rheumatoid arthritis 26 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 79 90.40 High High
Cancer 14 84.72 Quite High
INFLAMMATION 232 81.20 Quite High
Disease 126 76.36 Quite High
Autoimmune Disease 38 30.72 Quite Low
Injury 45 5.00 Very Low Very Low Very Low
Sepsis 40 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 26 5.00 Very Low Very Low Very Low
Infection 23 5.00 Very Low Very Low Very Low
Arthritis 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, active research on this topic is concerned with negatively regulating molecules that activate TLR-dependent signaling, but what about activating some of the natural inhibitory proteins, such as Triad3A, MyD88s, SHP-1, IRAK-M, IRAK1c, IRF4, and A20?
Regulation (some) of IRAK in A20
1) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.63 Pain Relevance 0.08
It involves the IL-1R-associated kinases (IRAK), IRAK-1 and IRAK-4, TNF receptor-associated factor 6 (TRAF-6), and mitogen-activated kinases (MAPK) and it culminates in the activation of the transcription factor NF?
Regulation (involves) of IRAK-1
2) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.08 Pain Relevance 0.08
It involves the IL-1R-associated kinases (IRAK), IRAK-1 and IRAK-4, TNF receptor-associated factor 6 (TRAF-6), and mitogen-activated kinases (MAPK) and it culminates in the activation of the transcription factor NF?
Regulation (involves) of IRAK
3) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.08 Pain Relevance 0.08
It involves the IL-1R-associated kinases (IRAK), IRAK-1 and IRAK-4, TNF receptor-associated factor 6 (TRAF-6), and mitogen-activated kinases (MAPK) and it culminates in the activation of the transcription factor NF?
Regulation (involves) of IRAK
4) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.08 Pain Relevance 0.08
Differential Ub of the same molecule, leading to distinct signaling outcomes, was first coined “ubiquitin editing” by Lam and colleagues to describe quantitative changes in ubiquitination (32) and was subsequently adopted by Newton and colleagues to describe the regulation of IL-1-induced IRAK-1 (33).
Regulation (regulation) of IRAK-1
5) Confidence 0.09 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.03

General Comments

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