INT324770

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.34
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bst2) Golgi apparatus (Bst2) plasma membrane (Bst2)
intracellular (Bst2) signal transducer activity (Bst2)
Bst2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 402 99.54 Very High Very High Very High
antagonist 18 88.68 High High
rheumatoid arthritis 42 82.32 Quite High
Pain 6 78.64 Quite High
Arthritis 18 75.92 Quite High
Inflammatory response 30 69.20 Quite High
cytokine 84 43.36 Quite Low
ischemia 12 5.64 Low Low
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 414 99.54 Very High Very High Very High
Disease 216 97.04 Very High Very High Very High
Infection 36 95.92 Very High Very High Very High
Injury 90 93.68 High High
Viral Infection 6 93.52 High High
Necrosis 18 90.84 High High
Sepsis 60 86.20 High High
Rheumatoid Arthritis 42 82.32 Quite High
Systemic Lupus Erythematosus 36 81.44 Quite High
Cancer 18 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the evidence that supports the idea that distinct molecular machinery is required for DAMP activation of TLRs, another strategy would be to block co-receptors or accessory molecules essential for DAMP activation.
Positive_regulation (activation) of DAMP
1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.80 Pain Relevance 0.24
DAMP activation of Toll-like receptors (TLRs) induces inflammatory gene expression to mediate tissue repair.
Positive_regulation (activation) of DAMP associated with inflammation
2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2913853 Disease Relevance 0.95 Pain Relevance 0.28
We have highlighted here the possible levels of intervention in DAMP activation of TLR-mediated inflammation, namely, manipulating DAMP activation of TLRs or controlling tissue level of DAMPs.
Positive_regulation (activation) of DAMP associated with inflammation
3) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.64 Pain Relevance 0.10
Indeed, as details of the mechanisms of endogenous TLR ligand recognition emerge, it becomes clear that there are significant differences between PAMP and DAMP activation of TLRs.
Positive_regulation (activation) of DAMP
4) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.33 Pain Relevance 0.05
Suppressing DAMP activation of TLRs offers a host of new potential targets for treating inflammatory diseases that may be viable alternatives to current approaches.
Positive_regulation (activation) of DAMP associated with inflammation and disease
5) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.93 Pain Relevance 0.35
We have highlighted here the possible levels of intervention in DAMP activation of TLR-mediated inflammation, namely, manipulating DAMP activation of TLRs or controlling tissue level of DAMPs.
Spec (possible) Positive_regulation (activation) of DAMP associated with inflammation
6) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.69 Pain Relevance 0.13

General Comments

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