INT324783

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.10
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bst2) Golgi apparatus (Bst2) plasma membrane (Bst2)
intracellular (Bst2) signal transducer activity (Bst2)
Bst2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 335 98.92 Very High Very High Very High
cytokine 70 83.76 Quite High
Paracetamol 5 78.20 Quite High
Inflammatory response 25 70.52 Quite High
Multiple sclerosis 20 57.64 Quite High
Arthritis 15 54.80 Quite High
rheumatoid arthritis 35 53.00 Quite High
ischemia 10 33.28 Quite Low
antagonist 15 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 25 99.06 Very High Very High Very High
Disease 180 99.00 Very High Very High Very High
INFLAMMATION 345 98.92 Very High Very High Very High
Gram Positive Bacterium Infection 5 89.68 High High
Sepsis 50 82.16 Quite High
Injury 75 79.04 Quite High
Infection 30 74.00 Quite High
Atherosclerosis 15 72.00 Quite High
Cancer 15 71.20 Quite High
Shock 20 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This evidence has come from mice that do not express specific endogenous TLR activators (Table 2) and studies showing that inhibition of DAMP function can ameliorate disease in vivo (Table 3) and we review these data below.
Negative_regulation (inhibition) of DAMP associated with disease
1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.00 Pain Relevance 0.35
Dysfunction of this pathway might contribute to the etiology of autoimmune diseases and likewise may offer a means to selectively inhibit DAMP activity [198].
Negative_regulation (inhibit) of DAMP associated with autoimmune disease
2) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.86 Pain Relevance 0.26
We also discuss the evidence that implicates endogenous molecules in pathological TLR activation and examine how blockade of DAMP action may be therapeutically beneficial.
Negative_regulation (blockade) of DAMP
3) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.40 Pain Relevance 0.39
Inhibition of DAMP Action In Vivo Ameliorates Disease
Negative_regulation (Inhibition) of DAMP associated with disease
4) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.11 Pain Relevance 0.36
This is mediated at least in part through CD24 association with Siglec-10/G causing activation of associated phosphatases which are proposed to repress DAMP-initiated signalling.
Negative_regulation (repress) of DAMP
5) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.73 Pain Relevance 0.22

General Comments

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