INT324783

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 5.10 Pain Relevance 1.58

signal transduction (Bst2) Golgi apparatus (Bst2) plasma membrane (Bst2) intracellular (Bst2) signal transducer activity (Bst2)

Bst2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 335 98.92 cytokine 70 83.76 Paracetamol 5 78.20 Inflammatory response 25 70.52 Multiple sclerosis 20 57.64 Arthritis 15 54.80 rheumatoid arthritis 35 53.00 ischemia 10 33.28 antagonist 15 5.00 agonist 10 5.00

Disease Link Frequency Relevance Heat Autoimmune Disease 25 99.06 Disease 180 99.00 INFLAMMATION 345 98.92 Gram Positive Bacterium Infection 5 89.68 Sepsis 50 82.16 Injury 75 79.04 Infection 30 74.00 Atherosclerosis 15 72.00 Cancer 15 71.20 Shock 20 70.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This evidence has come from mice that do not express specific endogenous TLR activators (Table 2) and studies showing that inhibition of DAMP function can ameliorate disease in vivo (Table 3) and we review these data below.

Negative_regulation (inhibition) of DAMP associated with disease

1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.00 Pain Relevance 0.35

Dysfunction of this pathway might contribute to the etiology of autoimmune diseases and likewise may offer a means to selectively inhibit DAMP activity [198].

Negative_regulation (inhibit) of DAMP associated with autoimmune disease

2) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.86 Pain Relevance 0.26

We also discuss the evidence that implicates endogenous molecules in pathological TLR activation and examine how blockade of DAMP action may be therapeutically beneficial.

Negative_regulation (blockade) of DAMP

3) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.40 Pain Relevance 0.39

Inhibition of DAMP Action In Vivo Ameliorates Disease

Negative_regulation (Inhibition) of DAMP associated with disease

4) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.11 Pain Relevance 0.36

This is mediated at least in part through CD24 association with Siglec-10/G causing activation of associated phosphatases which are proposed to repress DAMP-initiated signalling.

Negative_regulation (repress) of DAMP

5) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.73 Pain Relevance 0.22

General Comments

This test has worked.