INT324785

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bst2) Golgi apparatus (Bst2) plasma membrane (Bst2)
intracellular (Bst2) signal transducer activity (Bst2)
Bst2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 201 99.04 Very High Very High Very High
cytokine 42 76.12 Quite High
Arthritis 9 9.60 Low Low
rheumatoid arthritis 21 5.36 Low Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 207 99.04 Very High Very High Very High
Injury 45 99.04 Very High Very High Very High
Viral Infection 3 93.52 High High
Necrosis 9 90.84 High High
Disease 108 77.60 Quite High
Hepatotoxicity 6 70.52 Quite High
Reperfusion Injury 6 69.40 Quite High
Disease Progression 3 58.64 Quite High
Syndrome 3 51.00 Quite High
Infection 18 29.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, examining the stimuli that induce DAMP expression or release upon tissue injury will be important in establishing a “chain of command” of DAMP action.
Gene_expression (expression) of DAMP associated with injury
1) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.79 Pain Relevance 0.29
Thus targeting DAMP-mediated activation of TLRs may block this chronic inflammatory loop, although it will be important to assess whether total blockade of DAMP function will compromise tissue repair to any deleterious extent.
Gene_expression (targeting) of DAMP associated with inflammation
2) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.97 Pain Relevance 0.33
Indeed, as details of the mechanisms of endogenous TLR ligand recognition emerge, it becomes clear that there are significant differences between PAMP and DAMP activation of TLRs.
Gene_expression (activation) of DAMP
3) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.33 Pain Relevance 0.05

General Comments

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