INT324786

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bst2) Golgi apparatus (Bst2) plasma membrane (Bst2)
intracellular (Bst2) signal transducer activity (Bst2)
Bst2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 201 92.80 High High
Multiple sclerosis 12 69.00 Quite High
rheumatoid arthritis 21 64.36 Quite High
cytokine 42 60.92 Quite High
agonist 6 22.36 Low Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 207 92.80 High High
Disease 108 89.40 High High
Systemic Lupus Erythematosus 18 85.08 High High
Atherosclerosis 9 83.36 Quite High
Cancer 9 82.56 Quite High
Infection 18 74.60 Quite High
Demyelinating Disease 12 69.00 Quite High
Diabetes Mellitus 3 67.88 Quite High
Inflammatory Bowel Disease 6 67.16 Quite High
Rheumatoid Arthritis 21 64.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we review the mechanisms of DAMP recognition by TLRs, the signalling cascades, and the biological outcomes resulting from self TLR activation, focusing on the differences to non-self TLR activation.
DAMP Binding (recognition) of
1) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.48 Pain Relevance 0.35
These similarities and differences emerge below where we explore the mechanisms of PAMP and DAMP recognition by TLRs and the subsequent TLR signalling and biological outcomes.
DAMP Binding (recognition) of
2) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.14 Pain Relevance 0.06
This is a provisional list of endogenous activators and their accessory molecules that will certainly expand as we learn more about DAMP-TLR interactions.
DAMP Binding (interactions) of
3) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.15 Pain Relevance 0

General Comments

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