INT32480

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Context Info
Confidence 0.35
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gh1, Ghrh) extracellular region (Gh1, Ghrh) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
neurons 4
Gh1 (Rattus norvegicus)
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
Enkephalin 4 93.92 High High
Central nervous system 2 91.08 High High
Endogenous opioid 2 83.84 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most likely interpretation of such finding is that circulating GH disrupts, for a negative feedback effect, hypothalamic opioid function and/or GH-releasing hormone (GHRH) producing neurons, through which opioids exert their action.
GH Positive_regulation (disrupts) of Gene_expression (producing) of GHRH in neurons associated with opioid
1) Confidence 0.35 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2957419 Disease Relevance 0 Pain Relevance 0.58
The most likely interpretation of such finding is that circulating GH disrupts, for a negative feedback effect, hypothalamic opioid function and/or GH-releasing hormone (GHRH) producing neurons, through which opioids exert their action.
GH Positive_regulation (disrupts) of Gene_expression (producing) of GH-releasing hormone in neurons associated with opioid
2) Confidence 0.35 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2957419 Disease Relevance 0 Pain Relevance 0.58

General Comments

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