INT324806

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chuk, Myd88) cytosol (Chuk, Myd88) intracellular (Myd88)
protein complex (Myd88) signal transduction (Myd88) nucleus (Chuk)
Chuk (Mus musculus)
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 98.84 Very High Very High Very High
Inflammation 67 77.92 Quite High
Pain 1 51.60 Quite High
rheumatoid arthritis 7 47.20 Quite Low
Arthritis 3 39.28 Quite Low
ischemia 2 20.72 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 83.28 Quite High
INFLAMMATION 69 77.92 Quite High
Metastasis 2 73.24 Quite High
Lewis Lung Carcinoma 1 64.68 Quite High
Pneumonia 1 55.84 Quite High
Apoptosis 2 54.16 Quite High
Pain 1 51.60 Quite High
Targeted Disruption 2 49.72 Quite Low
Rheumatoid Arthritis 7 47.20 Quite Low
Arthritis 6 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Current strategies in clinical development for TLR blockade include (1) global blockade of individual TLR function using neutralizing antibodies, soluble TLR extracellular domains (ECDs), natural antagonists, and small molecule inhibitors, (2) inhibition of signalling pathways-activated downstream of TLR stimulation using small molecules to target MyD88/TRAF/IRAK complex formation, MAPK, or IKK activity, or (3) using PAMP antagonists such as LPS inhibitors.
Positive_regulation (target) of IKK Binding (formation) of MyD88 associated with antagonist
1) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.86 Pain Relevance 0.28

General Comments

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