INT324820

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) endoplasmic reticulum (Hsp90b1) intracellular (Tlr2)
cytoplasm (Tlr2) response to stress (Hsp90b1) cytosol (Hsp90b1)
Hsp90b1 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 96.96 Very High Very High Very High
Inflammation 134 96.60 Very High Very High Very High
agonist 4 84.76 Quite High
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 138 96.60 Very High Very High Very High
Infection 12 88.72 High High
Viral Infection 2 61.24 Quite High
Necrosis 6 58.56 Quite High
Systemic Lupus Erythematosus 12 57.44 Quite High
Syndrome 2 18.72 Low Low
Mycobacterial Infection 2 6.36 Low Low
Disease 72 5.00 Very Low Very Low Very Low
Injury 30 5.00 Very Low Very Low Very Low
Sepsis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among these, Gp96 and HMGB1 activate TLR2 and 4, whereas fibronectin EDA (FNEDA) and saturated fatty acids activate TLR4 [17, 20, 22, 81–86].
Gp96 Positive_regulation (activate) of TLR2
1) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.06 Pain Relevance 0.04
Further studies showed that HSP60 and Gp96 can tightly bind to LPS in a saturable manner and enhance its biological activity, as well as that of the TLR2 ligand Pam3Cys [43–45].
Gp96 Positive_regulation (enhance) of TLR2
2) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.36 Pain Relevance 0.13

General Comments

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