INT324866

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmgb1, Tlr4) cell morphogenesis (Hmgb1) intracellular (Tlr4)
DNA binding (Hmgb1) signal transduction (Tlr4) extracellular space (Hmgb1)
Hmgb1 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 75.60 Quite High
ischemia 4 73.60 Quite High
Inflammatory response 7 12.68 Low Low
agonist 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 32 96.44 Very High Very High Very High
Adult Respiratory Distress Syndrome 27 80.28 Quite High
Shock 7 79.96 Quite High
INFLAMMATION 15 75.60 Quite High
Injury 18 74.72 Quite High
Cv Unclassified Under Development 4 73.60 Quite High
Hepatitis 1 69.68 Quite High
Bacterial Respiratory Disease 1 18.56 Low Low
Stress 3 5.32 Low Low
Systemic Inflammatory Response Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have shown that HMGB1 is a potent activator of TLR4 [34].
HMGB1 Positive_regulation (activator) of TLR4
1) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 1.29 Pain Relevance 0.13

General Comments

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