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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.79
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, Ptgs1) nuclear envelope (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
endothelium 1
TNF (Homo sapiens)
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cOX1 1 100.00 Very High Very High Very High
psoriasis 63 94.88 High High
cytokine 2 73.92 Quite High
Inflammation 16 69.96 Quite High
Arthritis 2 36.56 Quite Low
methotrexate 1 21.12 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 31 99.42 Very High Very High Very High
Psoriasis 106 94.88 High High
Insulin Resistance 3 92.60 High High
Obesity 6 90.64 High High
Stress 10 82.68 Quite High
Coagulation Disorder 1 80.92 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 78.72 Quite High
Congenital Anomalies 11 78.16 Quite High
INFLAMMATION 18 69.96 Quite High
Syndrome 2 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
inhibitors affects the increase of HDL level [128]; in particular, TNF may affect endothelium dysfunction by decreasing the levels of nitric oxide synthase and cyclooxygenase 1 [127].


TNF Negative_regulation (decreasing) of cyclooxygenase 1 in endothelium associated with cox1 and disorder of lipid metabolism
1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.71 Pain Relevance 0.23

General Comments

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