INT325045

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.26 Pain Relevance 0.12

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1) DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)

Hand1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Central nervous system 36 90.80 Hippocampus 5 87.88 Inflammation 19 59.52 Neurotransmitter 3 5.84 chemokine 25 5.00 Glutamate 18 5.00 Inflammatory response 5 5.00 potassium channel 4 5.00 antagonist 3 5.00 cytokine 3 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 28 98.80 Acquired Immune Deficiency Syndrome Or Hiv Infection 83 96.60 Disease 12 76.60 Toxicity 4 76.00 Retinoblastoma 1 72.68 Infection 34 67.36 INFLAMMATION 26 59.52 Stress 14 5.00 Death 12 5.00 Dementia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, altered E2F1 function and a consequent disruption of DCX in HAND may cause an interruption in ANG, thereby contributing to the pathogenesis of these HIV-associated disorders.

Negative_regulation (disruption) of HAND associated with acquired immune deficiency syndrome or hiv infection and neurodegenerative disease

1) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.26 Pain Relevance 0.12

General Comments

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