INT325047

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.42
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
neuronal 2
Hand1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 133 99.36 Very High Very High Very High
Central nervous system 252 95.88 Very High Very High Very High
imagery 7 94.32 High High
antagonist 21 90.32 High High
cINOD 14 87.84 High High
transdermal 21 80.68 Quite High
Hippocampus 35 79.52 Quite High
Glutamate 126 76.80 Quite High
agonist 14 75.60 Quite High
Glutamate receptor 14 74.92 Quite High
Disease Link Frequency Relevance Heat
Disease 84 100.00 Very High Very High Very High
Death 84 99.48 Very High Very High Very High
INFLAMMATION 182 99.36 Very High Very High Very High
Neurodegenerative Disease 196 99.00 Very High Very High Very High
Retinoblastoma 7 98.96 Very High Very High Very High
Stress 98 98.70 Very High Very High Very High
Infection 238 98.28 Very High Very High Very High
Insulin Resistance 21 96.36 Very High Very High Very High
Viral Infection 7 95.24 Very High Very High Very High
Parkinson's Disease 7 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, cell cycle proteins, such as the transcription factor, E2F1, and its regulator, the retinoblastoma gene product, exhibit increased levels and altered expression patterns in Alzheimer’s Disease (AD), PD, and HAND postmortem tissue (Jordan-Sciutto et al. 2002a, b; Hoglinger et al. 2007).
Gene_expression (expression) of HAND associated with disease and retinoblastoma
1) Confidence 0.07 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.80 Pain Relevance 0.04
This finding implicates oxidative stress as an important mode of neuronal death in the indirect model of HAND neurodegeneration.
Gene_expression (neurodegeneration) of HAND in neuronal associated with stress and death
2) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.28 Pain Relevance 0.06
Neuropathogenesis of HAND: consequences of chronic neuroinflammation
Gene_expression (Neuropathogenesis) of HAND
3) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.08 Pain Relevance 0.03
Therapeutics for HAND; current trials and considerations
Gene_expression (Therapeutics) of HAND
4) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.23 Pain Relevance 0.06
Therapeutics for HAND; future considerations for adjunctive therapies
Gene_expression (Therapeutics) of HAND
5) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.44 Pain Relevance 0.40
Neuropathogenesis of HAND: mechanisms of inflammation-induced neuronal insults
Gene_expression (Neuropathogenesis) of HAND in neuronal associated with inflammation
6) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.04 Pain Relevance 0.28
Neuropathogenesis of HAND: overview
Gene_expression (Neuropathogenesis) of HAND
7) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.54 Pain Relevance 0.20

General Comments

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