INT325051

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Hand1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 79.52 Quite High
Inflammation 38 47.04 Quite Low
Central nervous system 72 43.20 Quite Low
Glutamate 36 29.52 Quite Low
Action potential 6 23.60 Low Low
potassium channel 8 7.04 Low Low
chemokine 50 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 100.00 Very High Very High Very High
Disease 24 100.00 Very High Very High Very High
Retinoblastoma 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 166 93.12 High High
Neurodegenerative Disease 56 89.68 High High
Death 24 84.28 Quite High
Parkinson's Disease 2 78.36 Quite High
Infection 68 65.04 Quite High
Disease Progression 2 55.20 Quite High
INFLAMMATION 52 47.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings demonstrate a significant pathogenic role for oxidative stress in HAND, and suggest that the endogenous cellular antioxidant response may serve as a potential therapeutic target in this disease.


Regulation (role) of HAND associated with stress and disease
1) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.06 Pain Relevance 0
Interestingly, cell cycle proteins, such as the transcription factor, E2F1, and its regulator, the retinoblastoma gene product, exhibit increased levels and altered expression patterns in Alzheimer’s Disease (AD), PD, and HAND postmortem tissue (Jordan-Sciutto et al. 2002a, b; Hoglinger et al. 2007).
Regulation (regulator) of HAND associated with disease and retinoblastoma
2) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox