INT325053

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.02
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) DNA binding (E2f1)
transcription factor binding (E2f1) cytoplasm (E2f1)
E2f1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 89.44 High High
Central nervous system 72 86.64 High High
Inflammation 38 55.36 Quite High
Glutamate 36 21.88 Low Low
potassium channel 8 7.60 Low Low
chemokine 50 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
transdermal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 99.76 Very High Very High Very High
Neurodegenerative Disease 56 96.72 Very High Very High Very High
Disease 24 95.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 166 94.52 High High
Toxicity 8 71.84 Quite High
Infection 68 65.60 Quite High
INFLAMMATION 52 55.36 Quite High
Apoptosis 4 15.12 Low Low
Death 24 9.28 Low Low
Stress 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, cell cycle proteins, such as the transcription factor, E2F1, and its regulator, the retinoblastoma gene product, exhibit increased levels and altered expression patterns in Alzheimer’s Disease (AD), PD, and HAND postmortem tissue (Jordan-Sciutto et al. 2002a, b; Hoglinger et al. 2007).
Regulation (regulator) of E2F1 associated with disease and retinoblastoma
1) Confidence 0.19 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.79 Pain Relevance 0.03
Thus, altered E2F1 function and a consequent disruption of DCX in HAND may cause an interruption in ANG, thereby contributing to the pathogenesis of these HIV-associated disorders.
Regulation (altered) of E2F1 associated with acquired immune deficiency syndrome or hiv infection and neurodegenerative disease
2) Confidence 0.11 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.23 Pain Relevance 0.12

General Comments

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