INT325055

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
neuronal 1
Hand1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 76 91.12 High High
Central nervous system 144 87.44 High High
cINOD 8 82.96 Quite High
antagonist 12 81.24 Quite High
Inflammatory response 20 75.48 Quite High
imagery 4 69.44 Quite High
transdermal 12 55.80 Quite High
monoamine 8 46.56 Quite Low
Glutamate 72 23.00 Low Low
chemokine 100 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 48 99.96 Very High Very High Very High
Disease 48 99.92 Very High Very High Very High
Diabetes Mellitus 12 99.64 Very High Very High Very High
Stroke 4 99.50 Very High Very High Very High
Disease Progression 4 97.84 Very High Very High Very High
Stress 56 92.48 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 332 92.16 High High
INFLAMMATION 104 91.12 High High
Anxiety Disorder 12 85.28 High High
Parkinson's Disease 4 51.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to neuronal death, HAND is associated with neuronal damage, particularly synaptic disruption.
HAND Binding (associated) of in neuronal associated with death
1) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.92 Pain Relevance 0.08
It is clear that the possibilities for future HAND treatments abound and that novel classes of potential neuroprotectant agents as well as increased duration of clinical trial testing and novel routes of administration should be strongly considered in future trials.



HAND Binding (abound) of
2) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.45 Pain Relevance 0.17
IND of insulin and other molecules has been demonstrated to mitigate many of the behavioral and pathological deficits associated with HAND and other ND.
HAND Binding (associated) of
3) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.16 Pain Relevance 0.04
The development of intranasal delivery (IND) of neurotrophin, insulin, and IGF-1 has emerged as a potential therapeutic technique to reduce damage associated with stroke and memory degeneration associated with HAND, AD, or diabetes (Kern et al. 1999; Thorne and Frey 2001; Benedict et al. 2004; Thorne et al. 2004, 2008; Ross et al. 2004; Reger et al. 2008a; Reger et al. 2008b; Hanson and Frey 2007; Reagan 2007; Ross et al. 2008).
HAND Binding (associated) of associated with diabetes mellitus, stroke and disease
4) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.61 Pain Relevance 0.29

General Comments

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