INT3252

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 428
Total Number 431
Disease Relevance 271.65
Pain Relevance 39.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 38
blood 16
fat 12
skeletal muscle 6
muscle 6
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 704 100.00 Very High Very High Very High
Somatostatin 226 100.00 Very High Very High Very High
medulla 81 100.00 Very High Very High Very High
dexamethasone 18 100.00 Very High Very High Very High
midbrain 11 100.00 Very High Very High Very High
narcan 42 99.98 Very High Very High Very High
abdominal pain 31 99.98 Very High Very High Very High
Intracerebroventricular 10 99.98 Very High Very High Very High
antagonist 238 99.96 Very High Very High Very High
Eae 24 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 3363 100.00 Very High Very High Very High
Hypoglycemia 2799 100.00 Very High Very High Very High
Insulin Resistance 2484 100.00 Very High Very High Very High
Hypertension 849 100.00 Very High Very High Very High
Impaired Glucose Tolerance 730 100.00 Very High Very High Very High
Weight Loss 721 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 701 100.00 Very High Very High Very High
Pressure And Volume Under Development 407 100.00 Very High Very High Very High
Vomiting 363 100.00 Very High Very High Very High
Hyperphagia 50 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immediately after acupuncture, independent of the stimulation technique used, a significant short-term decrease in insulin concentration was observed.
Negative_regulation (decrease) of insulin associated with acupuncture
1) Confidence 0.59 Published 1984 Journal Acupunct Electrother Res Section Abstract Doc Link 6145307 Disease Relevance 0 Pain Relevance 0.31
Diabetes is either type 1, as a result of frank deficiency of insulin or type 2, due to resistance of tissue to respond insulin.
Negative_regulation (deficiency) of insulin associated with diabetes mellitus
2) Confidence 0.59 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.70 Pain Relevance 0
The potential for a decreased amount of absorbed insulin over repeated administration with jet injectors is a disadvantage.
Negative_regulation (decreased) of insulin
3) Confidence 0.59 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.25 Pain Relevance 0.09
Public health strategies to reduce insulin resistance in middle-aged individuals could therefore encourage people to increase their overall PAEE by devoting more time to moderate and perhaps even vigorous activities.



Negative_regulation (reduce) of insulin associated with insulin resistance
4) Confidence 0.59 Published 2008 Journal Diabetologia Section Body Doc Link PMC2491413 Disease Relevance 0.18 Pain Relevance 0
In comparison, there was a decrease in those receiving insulin glargine and this was almost entirely due to a reduction in the daily basal insulin dose seen in those patients previously using a twice-daily NPH insulin regimen.
Negative_regulation (decrease) of insulin
5) Confidence 0.59 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.27 Pain Relevance 0
In a study of non-diabetic subjects with mild to moderate asthma, it was demonstrated that compared to healthy subjects, the overall exposure to insulin (AUC) was 34% to 41% less.51 The glucodynamic effects of inhaled insulin were comparable between healthy and subjects with mild asthma, while the ability of inhaled insulin to lower serum glucose was decreased in subjects with moderate asthma.
Negative_regulation (decreased) of insulin associated with asthma and diabetes mellitus
6) Confidence 0.59 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 1.58 Pain Relevance 0.11
During intraduodenal infusion of glucose, insulin concentrations in plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP.
Negative_regulation (decreased) of insulin in plasma associated with morphine
7) Confidence 0.59 Published 1986 Journal Diabetes Section Abstract Doc Link 3512343 Disease Relevance 0 Pain Relevance 0.52
The absence of any marked impairment in glucose tolerance in the oral test in spite of the decreased insulin response suggests that enkephalin might have an additional effect in delaying glucose absorption.
Negative_regulation (decreased) of insulin associated with tolerance, enkephalin and impaired glucose tolerance
8) Confidence 0.58 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6353831 Disease Relevance 0.33 Pain Relevance 0.57
To evaluate the hypothesis that an increased sensitivity to these endogenous substances may play a role in defective insulin secretion in diabetes, we evaluated the effects of three blocking drugs upon the impaired insulin response to glucose in Type II diabetic subjects, as well as glucose-induced insulin secretion in normal humans.
Negative_regulation (impaired) of insulin associated with diabetes mellitus
9) Confidence 0.58 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3936737 Disease Relevance 0.68 Pain Relevance 0.21
She was given a trial of insulin lispro with immediate and dramatic effects, lowering her HbA1c from 14.6 to 5.1% in 7 months with a decrease in insulin requirements of 1600-100 U per day.
Negative_regulation (decrease) of insulin
10) Confidence 0.58 Published 1998 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 9829349 Disease Relevance 1.35 Pain Relevance 0.18
Insulin sensitivity was greatly impaired by anesthesia with isoflurane, but was not affected by use of the anxiolytic agent diazepam.
Negative_regulation (impaired) of Insulin associated with anesthesia, anxiety disorder and isoflurane
11) Confidence 0.58 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.27 Pain Relevance 0.24
Significant decreases in insulin and hypoglycemic medication requirement were also observed in the low carbohydrate diet group.
Negative_regulation (decreases) of insulin
12) Confidence 0.58 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 0.76 Pain Relevance 0
In another study [29], significant decreases in insulin to glucose ratio were seen in the LoCHO group suggesting improved insulin sensitivity, especially in subjects with insulin resistance and higher baseline insulin levels.
Negative_regulation (decreases) of insulin associated with insulin resistance
13) Confidence 0.58 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 0.97 Pain Relevance 0
Furthermore, it is likely to be a result of local insulin deficiency rather than sustained high levels of insulin [71,72], since in AD patients the csf to plasma insulin ratio is particularly low and negatively related to the severity of AD [73].
Negative_regulation (deficiency) of insulin in plasma associated with disease
14) Confidence 0.57 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.22 Pain Relevance 0.06
Subjects in the fluoxetine group also showed a greater percentage decrease in insulin dose than those in the placebo group (46.9 +/- 7.6% vs. 19.3 +/- 7.6%, P less than 0.01).
Negative_regulation (decrease) of insulin associated with fluoxetine
15) Confidence 0.57 Published 1992 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 1317828 Disease Relevance 0.60 Pain Relevance 0.60
Adding rosiglitazone to insulin therapy was found to reduce glycated haemoglobin (HbA1c) by 1.2% (P < 0.001), along with a 12% reduction of insulin dosage, but with increased oedema and weight gain [19,20].
Negative_regulation (reduction) of insulin associated with pressure and volume under development and weight gain
16) Confidence 0.57 Published 2007 Journal Diabetic Medicine Section Body Doc Link PMC1974817 Disease Relevance 0.55 Pain Relevance 0
BACKGROUND: Painful trauma results in a disturbed metabolic state with impaired insulin sensitivity, which is related to the magnitude of the trauma.
Negative_regulation (impaired) of insulin associated with pain and injury
17) Confidence 0.57 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11575527 Disease Relevance 0.44 Pain Relevance 0.27
Akita mice have reduced numbers of beta cells and reduced pancreatic insulin content.
Negative_regulation (reduced) of insulin in beta cells
18) Confidence 0.57 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 1.03 Pain Relevance 0.08
The decrease in insulin appeared more marked after resection plus occlusion as compared with the non-occluded group.
Negative_regulation (decrease) of insulin
19) Confidence 0.57 Published 1986 Journal Hepatogastroenterology Section Abstract Doc Link 3530929 Disease Relevance 0.40 Pain Relevance 0.32
The decrease in the proinsulin-to-insulin ratio and increase in C-peptide concentration from baseline for the liraglutide groups were significant (P < 0.05 for both) compared with the placebo group.
Negative_regulation (decrease) of proinsulin
20) Confidence 0.57 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990388 Disease Relevance 0.30 Pain Relevance 0

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