INT325204

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh4) plasma membrane (Hrh4) signal transducer activity (Hrh4)
Anatomy Link Frequency
lymph node 1
Hrh4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 80 99.96 Very High Very High Very High
cytokine 60 99.36 Very High Very High Very High
Inflammation 74 70.04 Quite High
Serotonin 4 14.28 Low Low
chemokine 10 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 86 99.60 Very High Very High Very High
INFLAMMATION 66 70.04 Quite High
Hypersensitivity 22 64.80 Quite High
Hyperplasia 26 34.40 Quite Low
Rhinitis 6 12.80 Low Low
Pneumonia 8 5.00 Very Low Very Low Very Low
Airway Remodeling 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Airway Obstruction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of H4R antagonist treatment on underlying T cell responses in the model was determined by examining draining lymph node proliferation and cytokine production in response to antigen specific stimulation.
Regulation (effect) of H4R in lymph node associated with antagonist and cytokine
1) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.16 Pain Relevance 0.40
Consequently, we utilized another well-described model to initiate airway hyperreactivity and to examine the effect of H4R antagonists and anti-IL-13 on this parameter.
Spec (examine) Regulation (effect) of H4R associated with asthma and antagonist
2) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.81 Pain Relevance 0.12

General Comments

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