INT325207

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh4) plasma membrane (Hrh4) signal transducer activity (Hrh4)
Anatomy Link Frequency
memory T cells 2
Hrh4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 90 93.48 High High
antagonist 120 86.88 High High
Inflammation 111 76.88 Quite High
chemokine 15 22.00 Low Low
Serotonin 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Antihistamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 129 89.44 High High
Hyperplasia 39 84.84 Quite High
INFLAMMATION 99 76.88 Quite High
Fibrosis 3 70.00 Quite High
Pneumonia 12 59.84 Quite High
Disease 6 51.68 Quite High
Hypersensitivity 33 50.44 Quite High
Rhinitis 9 14.56 Low Low
Airway Remodeling 6 5.00 Very Low Very Low Very Low
Airway Obstruction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may result from the continued activation of memory T cells in the more chronic setting, and its progressive attenuation under H4R blockade.
Negative_regulation (attenuation) of Gene_expression (blockade) of H4R in memory T cells
1) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.14 Pain Relevance 0.32
All of these parameters were blocked both by H4R antagonism and anti-IL-13 treatment.
Negative_regulation (blocked) of Gene_expression (antagonism) of H4R
2) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.83 Pain Relevance 0.17
Treatment with both H4R, 20 mg/kg, and anti-IL-13 reduced free collagen levels (vehicle, 55.83 ± 2.4 ?
Negative_regulation (reduced) of Gene_expression (Treatment) of H4R
3) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.89 Pain Relevance 0.17

General Comments

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