INT325230

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 1.47
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il33) extracellular region (Il33) nucleus (Il33)
Anatomy Link Frequency
mast cells 10
skin 2
Il33 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 187 98.28 Very High Very High Very High
Inflammation 319 87.28 High High
Inflammatory response 55 78.80 Quite High
Inflammatory stimuli 11 49.36 Quite Low
fibrosis 11 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 242 89.60 High High
INFLAMMATION 385 87.28 High High
Sprains And Strains 33 87.28 High High
Obesity 11 52.60 Quite High
Disease 55 36.12 Quite Low
Pressure And Volume Under Development 33 35.28 Quite Low
Inflammatory Bowel Disease 11 30.64 Quite Low
Conjunctiva Disease 11 29.20 Quite Low
Asthma 22 28.00 Quite Low
Increased Venous Pressure Under Development 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 4C shows that IL-33 levels were significantly elevated at IgE-primed skin sites versus the sham (PBS) injected skin of the same mouse.
Positive_regulation (elevated) of Gene_expression (levels) of IL-33 in skin
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.21 Pain Relevance 0.03
Together, these data demonstrate that the expression of IL-33 by mast cells is dependent upon calcium activation, such as occurs via IgE/Fc?
Positive_regulation (upon) of Gene_expression (expression) of IL-33 in mast cells
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.03
Mast cells express IL-33 constitutively and upon activation in vivo
Positive_regulation (upon) of Gene_expression (express) of IL-33 in Mast cells
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.14 Pain Relevance 0
IL-33 expression by mast cells is dependent on calcium and not induced by IL-33
Neg (not) Positive_regulation (by) of Gene_expression (expression) of IL-33 in mast cells
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.08
This was antigen specific, since DNP-HSA stimulated expression of IL-33 in mast cells primed with DNP-specific IgE but not OVA-specific IgE while concomitantly, OVA induced expression in these cells (Figure 1B).
Neg (not) Positive_regulation (stimulated) of Gene_expression (expression) of IL-33 in mast cells
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.05
and IL-18 were also increased (data not shown), the expression of IL-33 was more than ten fold higher than either of these related cytokines.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of IL-33 associated with cytokine
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.05
Interestingly, IL-33 fails to induce its own expression and we show a requirement for calcium-mediated processes in IL-33 expression.
Positive_regulation (requirement) of Gene_expression (expression) of IL-33
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.45 Pain Relevance 0.15
This occurs in response to IgE-mediated activation but not to IL-33-driven activation and we believe that this is likely due to the lack of calcium activation from ST2, compared to Fc?
Positive_regulation (activation) of Gene_expression (activation) of IL-33-driven
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.47 Pain Relevance 0.09
The expression of IL-4, IL-5, IL-6 and IL-33 were induced in BMMC (Figure 2A) after either stimulation.
Positive_regulation (induced) of Gene_expression (expression) of IL-33
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
Our quantitative data shows that the expression of IL-33 by mast cells occurs in response to IgE-mediated activation but not to IL-33 concentrations that potently activated production of other cytokines, suggesting that autocrine amplification is unlikey.
Positive_regulation (occurs) of Gene_expression (expression) of IL-33 in mast cells associated with cytokine
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.20 Pain Relevance 0.22
We found that IL-33 protein was detectable in unstimulated cells and enhanced in IgE/DNP stimulated cells (Figure 1C).
Positive_regulation (enhanced) of Gene_expression (detectable) of IL-33 protein
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.04

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