INT325269

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Il33, Spg21) cytosol (Spg21) extracellular space (Il33)
extracellular region (Il33) biological_process (Spg21) cytoplasm (Spg21)
Anatomy Link Frequency
mast cell 3
Il33 (Mus musculus)
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 51 99.76 Very High Very High Very High
Inflammation 87 90.52 High High
Inflammatory response 15 48.72 Quite Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 66 99.32 Very High Very High Very High
INFLAMMATION 105 90.52 High High
Disease 15 77.16 Quite High
Asthma 6 75.96 Quite High
Pressure And Volume Under Development 9 66.48 Quite High
Rhinitis 3 16.32 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Anaemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-33 itself has been shown to be a potent inducer of mast cell cytokine production [15], [16], [17], [38], independent of Fc?
IL-33 Positive_regulation (inducer) of mast in mast cell associated with cytokine
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
Recombinant IL-33 has been shown to enhance mast cell responses in murine anaphylactic shock and these authors concluded that IL-33 enhances mast cell reactivity to IgE stimulation [19].
IL-33 Positive_regulation (enhances) of mast in mast cell associated with anaphylaxis
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.39 Pain Relevance 0.07
Conversely, recombinant IL-33 directly activated mast cells to produce several cytokines including IL-4, IL-5 and IL-6 but not IL-33.
recombinant IL-33 Neg (not) Positive_regulation (activated) of mast in mast cells associated with cytokine
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.73 Pain Relevance 0.31

General Comments

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