INT3253

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 205
Total Number 212
Disease Relevance 130.39
Pain Relevance 36.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 12
fat 11
pancreas 10
blood 8
pancreatic islets 6
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 253 100.00 Very High Very High Very High
aspirin 57 100.00 Very High Very High Very High
narcan 47 100.00 Very High Very High Very High
Analgesic 17 100.00 Very High Very High Very High
Nerve growth factor 14 100.00 Very High Very High Very High
Clonidine 36 99.98 Very High Very High Very High
Paracetamol 19 99.98 Very High Very High Very High
Morphine 15 99.98 Very High Very High Very High
Dopamine 45 99.96 Very High Very High Very High
tolerance 349 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 5698 100.00 Very High Very High Very High
Insulin Resistance 851 100.00 Very High Very High Very High
Repression 58 100.00 Very High Very High Very High
Gastric Motility Disorder 34 100.00 Very High Very High Very High
Obesity 1615 99.98 Very High Very High Very High
Hypothermia 139 99.98 Very High Very High Very High
Impaired Glucose Tolerance 372 99.90 Very High Very High Very High
Hyperglycemia 354 99.90 Very High Very High Very High
Hyperinsulinism 258 99.90 Very High Very High Very High
Pompes Disease 1 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surgical stress with inhalation anesthesia is associated with increased circulating catecholamines, hyperglycemia, and impaired insulin secretion.
Negative_regulation (impaired) of Localization (secretion) of insulin associated with hyperglycemia, stress, anesthesia and catecholamine
1) Confidence 0.59 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.55 Pain Relevance 0.49
Prostaglandin E (PGE), epinephrine and metenkephalin are three endogenous substances normally present in the endocrine pancreas which have been reported to inhibit glucose-induced insulin secretion in normal humans.
Negative_regulation (inhibit) of Localization (secretion) of insulin in endocrine pancreas
2) Confidence 0.59 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0 Pain Relevance 0.16
In the postoperative period, however, suppressed insulin secretion was found to be correlated with elevated plasma epinephrine concentrations and may, therefore, be mediated by adrenergic mechanisms.
Negative_regulation (suppressed) of Localization (secretion) of insulin in plasma
3) Confidence 0.59 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.56 Pain Relevance 0.59
Thus, these findings indicate that impaired insulin secretion during surgical stress may have two etiologies--one related to the type of anesthesia used and the other due to adrenomedullary stimulation due to pain.
Negative_regulation (impaired) of Localization (secretion) of insulin associated with stress, pain and anesthesia
4) Confidence 0.59 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.63 Pain Relevance 0.60
An increase of catecholamines appears to increase glucose while both reducing insulin release and reducing sensitivity to insulin that is available.
Negative_regulation (reducing) of Localization (release) of insulin associated with catecholamine
5) Confidence 0.59 Published 2001 Journal Ann Clin Psychiatry Section Abstract Doc Link 11465683 Disease Relevance 0.89 Pain Relevance 0.64
Insulin secretion decreases with increased hyperglycemia (g1ucotoxicity), and diabetic subjects have increased levels of proinsulin, which is recognized by some (but not all) insulin assays.21 Insulin is reported to have considerable cross-reactivity with proinsulin.19,20,22 While the euglycemic clamp test is widely regarded as the 'gold standard' for sensitivity measurement, it remains a laboratory procedure, because it requires sophisticated equipment, highly trained personnel, and is a lengthy procedure.
Negative_regulation (decreases) of Localization (secretion) of Insulin associated with hyperglycemia and diabetes mellitus
6) Confidence 0.59 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 0.92 Pain Relevance 0.09
However, the disease is characterized by a gradual decline in insulin secretion in response to nutrient loading, making the third component of the glucose triad – postprandial plasma glucose – an important consideration for effective disease management.
Negative_regulation (decline) of Localization (secretion) of insulin in plasma associated with disease
7) Confidence 0.59 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.42 Pain Relevance 0
Diabetes mellitus represents a heterogeneous group of metabolic disorders which are characterized by hyperglycemia as a result of severe insulin deficiency (type 1 diabetes) or defects in insulin resistance, impaired insulin secretion, and increased glucose production (type 2 diabetes).
Negative_regulation (impaired) of Localization (secretion) of insulin associated with hyperglycemia, metabolic disorder, diabetes mellitus and insulin resistance
8) Confidence 0.59 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 2.10 Pain Relevance 0
Diabetes mellitus represents a heterogeneous group of metabolic disorders which are characterized by hyperglycemia as a result of severe insulin deficiency (type 1 diabetes) or defects in insulin resistance, impaired insulin secretion, and increased glucose production (type 2 diabetes).
Negative_regulation (defects) of Localization (secretion) of insulin associated with hyperglycemia, metabolic disorder, diabetes mellitus and insulin resistance
9) Confidence 0.59 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 2.12 Pain Relevance 0
The infusion of exogenous PGE1 (0.2 microgram X kg-1 X min-1) or PGE2 (10 micrograms/min) in addition to lysine acetylsalicylate restored the typical biphasic pattern of insulin release and also decreased total insulin release to values similar to those of control studies.
Negative_regulation (decreased) of Localization (release) of insulin
10) Confidence 0.58 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6419621 Disease Relevance 0 Pain Relevance 0
These observations demonstrate that in man, enkephalin produces a decrease in insulin secretion in response to both oral and iv glucose loads.
Negative_regulation (decrease) of Localization (secretion) of insulin associated with enkephalin
11) Confidence 0.58 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6353831 Disease Relevance 0.34 Pain Relevance 0.58
Impaired insulin secretion in human diabetes mellitus.
Negative_regulation (Impaired) of Localization (secretion) of insulin associated with diabetes mellitus and analgesic
12) Confidence 0.58 Published 1985 Journal Diabete Metab Section Title Doc Link 3936737 Disease Relevance 0.65 Pain Relevance 0.47
Relationship of impaired insulin secretion during surgical stress to anesthesia and catecholamine release.
Negative_regulation (impaired) of Localization (secretion) of insulin associated with stress, anesthesia and catecholamine
13) Confidence 0.58 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6999007 Disease Relevance 0.66 Pain Relevance 0.50
Thus, inhibition of insulin secretion during surgical stress may be mediated both by direct effect of the anesthesia used and by activation of the sympathetic nervous system.
Negative_regulation (inhibition) of Localization (secretion) of insulin in sympathetic nervous system associated with stress and anesthesia
14) Confidence 0.58 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6999007 Disease Relevance 0.67 Pain Relevance 0.52
Impaired insulin secretion has been observed during surgical stress in man.
Negative_regulation (Impaired) of Localization (secretion) of insulin associated with stress
15) Confidence 0.58 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6999007 Disease Relevance 0.52 Pain Relevance 0.36
Impaired insulin secretion in human diabetes mellitus.
Negative_regulation (Impaired) of Localization (secretion) of insulin associated with diabetes mellitus and narcan
16) Confidence 0.58 Published 1982 Journal Diabetes Section Title Doc Link 6295856 Disease Relevance 0.49 Pain Relevance 0.49
Type 2 diabetes is a progressive disease characterized by defects in insulin secretion and utilization [7].
Negative_regulation (defects) of Localization (secretion) of insulin associated with diabetes mellitus and disease
17) Confidence 0.58 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.84 Pain Relevance 0
Although all animals in groups I-III had normal fasting glucose levels and normal K-values at each test interval, a 75% reduction of insulin secretion after duct-obliterated transplantation was observed.
Negative_regulation (reduction) of Localization (secretion) of insulin in duct
18) Confidence 0.58 Published 1988 Journal Transplantation Section Abstract Doc Link 3061072 Disease Relevance 0 Pain Relevance 0.17
Disturbance of functional islet architecture appears to be the main causative factor in the decrease in insulin secretion.
Negative_regulation (decrease) of Localization (secretion) of insulin
19) Confidence 0.58 Published 1988 Journal Transplantation Section Abstract Doc Link 3061072 Disease Relevance 0 Pain Relevance 0.15
Instead, a more convenient and valid insulin sensitivity test involving suppression of insulin secretion with somatostatin and a single insulin injection was used.
Negative_regulation (suppression) of Localization (secretion) of insulin associated with somatostatin
20) Confidence 0.58 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.33 Pain Relevance 0.23

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